Publications by authors named "Siamak Mehrkanoon"

Article Synopsis
  • The study examined genetic interactions influencing bladder cancer (BC) risk using data from the UK Biobank, including over 4,000 Caucasian and non-Caucasian participants.
  • Researchers employed a machine learning approach to explore SNP-SNP interactions, identifying 10 significant pairs of SNPs related to BC risk, with some showing both positive and negative associations.
  • An integrated interaction-empowered polygenic risk score (iPRS) was developed, demonstrating a higher predictive capability for identifying high-risk individuals compared to traditional polygenic risk scores.
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Deep learning (DL) applied to breast tissue segmentation in magnetic resonance imaging (MRI) has received increased attention in the last decade, however, the domain shift which arises from different vendors, acquisition protocols, and biological heterogeneity, remains an important but challenging obstacle on the path towards clinical implementation. In this paper, we propose a novel Multi-level Semantic-guided Contrastive Domain Adaptation (MSCDA) framework to address this issue in an unsupervised manner. Our approach incorporates self-training with contrastive learning to align feature representations between domains.

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Article Synopsis
  • The study investigates how dietary patterns influence glucose metabolism and explores the role of metabolites in this relationship, focusing on prediabetes and type 2 diabetes.
  • Data was collected from The Maastricht Study involving 3441 participants, and both short-term and long-term effects were analyzed through various dietary patterns and their related metabolites.
  • Results indicated that certain metabolites, particularly APOA1 and DHA, were consistently associated with improved glucose metabolism, suggesting that a healthy diet could potentially mitigate diabetes risk through metabolic pathways.
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Objectives: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) risk and whether this PRS can be offset by a healthy lifestyle.

Methods: Individuals with BC (n = 563) and non-BC controls (n = 483 957) were identified in the UK Biobank, and adjusted Cox regression models were used. A PRS was constructed based on 34 genetic variants associated with BC development, while a healthy lifestyle score (HLS) was constructed based on three lifestyle factors (i.

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Weather nowcasting consists of predicting meteorological components in the short term at high spatial resolutions. Due to its influence in many human activities, accurate nowcasting has recently gained plenty of attention. In this paper, we treat the nowcasting problem as an image-to-image translation problem using satellite imagery.

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Background: Although a potential inverse association between vegetable intake and bladder cancer risk has been reported, epidemiological evidence is inconsistent. This research aimed to elucidate the association between vegetable intake and bladder cancer risk by conducting a pooled analysis of data from prospective cohort studies.

Methods: Vegetable intake in relation to bladder cancer risk was examined by pooling individual-level data from 13 cohort studies, comprising 3203 cases among a total of 555,685 participants.

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Background: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer.

Objectives: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber.

Methods: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC.

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This paper introduces novel deep architectures using the hybrid neural-kernel core model as the first building block. The proposed models follow a combination of a neural networks based architecture and a kernel based model enriched with pooling layers. In particular, in this context three kernel blocks with average, maxout and convolutional pooling layers are introduced and examined.

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Domain adaptation learning is one of the fundamental research topics in pattern recognition and machine learning. This paper introduces a regularized semipaired kernel canonical correlation analysis formulation for learning a latent space for the domain adaptation problem. The optimization problem is formulated in the primal-dual least squares support vector machine setting where side information can be readily incorporated through regularization terms.

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This letter addresses the robustness problem when learning a large margin classifier in the presence of label noise. In our study, we achieve this purpose by proposing robustified large margin support vector machines. The robustness of the proposed robust support vector classifiers (RSVC), which is interpreted from a weighted viewpoint in this work, is due to the use of nonconvex classification losses.

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This paper introduces an on-line semi-supervised learning algorithm formulated as a regularized kernel spectral clustering (KSC) approach. We consider the case where new data arrive sequentially but only a small fraction of it is labeled. The available labeled data act as prototypes and help to improve the performance of the algorithm to estimate the labels of the unlabeled data points.

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This paper proposes a multiclass semisupervised learning algorithm by using kernel spectral clustering (KSC) as a core model. A regularized KSC is formulated to estimate the class memberships of data points in a semisupervised setting using the one-versus-all strategy while both labeled and unlabeled data points are present in the learning process. The propagation of the labels to a large amount of unlabeled data points is achieved by adding the regularization terms to the cost function of the KSC formulation.

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In this paper, a new approach based on least squares support vector machines (LS-SVMs) is proposed for solving linear and nonlinear ordinary differential equations (ODEs). The approximate solution is presented in closed form by means of LS-SVMs, whose parameters are adjusted to minimize an appropriate error function. For the linear and nonlinear cases, these parameters are obtained by solving a system of linear and nonlinear equations, respectively.

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