Pharmacogenomics-based systematic review of coronary artery disease based on personalized medicine procedure.

Background: Coronary artery disease (CAD) is the most common reason for mortality and disability-adjusted life years (DALYs) lost globally. This study aimed to suggest a new gene list for the treatment of CAD by a systematic review of bioinformatics analyses of pharmacogenomics impacts of potential genes and variants.

Methods: PubMed search was filtered by the title including Coronary Artery Disease during 2020-2023.

Progress in cardiac tissue engineering and regeneration: Implications of gelatin-based hybrid scaffolds.

Cardiovascular diseases, particularly myocardial infarction (MI), remain a leading cause of morbidity and mortality worldwide. Current treatments for MI, more palliative than curative, have limitations in reversing the disease completely. Tissue engineering (TE) has emerged as a promising strategy to address this challenge and may lead to improved therapeutic approaches for MI.

Glucosinolates in cancer prevention and treatment: experimental and clinical evidence.

Glucosinolates are naturally occurring β-d-thioglucosides that mainly exist in the Brassicaceae family. The enzyme myrosinase hydrolyzes glucosinolates to form isothiocyanates, which are chemical protectors. Phenethyl isothiocyanate, sulforaphane, and benzyl isothiocyanate are potential isothiocyanate with efficient anti-cancer effects as a protective or treatment agent.

The recent advancement in the chitosan hybrid-based scaffolds for cardiac regeneration after myocardial infarction.

Acute myocardial infarction (AMI), which cut down blood flow to the myocardium, is a serious health-threatening disorder that causes remarkable morbidity and mortality. To date, scaffolds have opened new prospects for potential applications for cardiac regeneration after AMI. The hybrid scaffolds as novel strategies can improve the performance of scaffolds.

The recent progress in the early diagnosis of acute myocardial infarction based on myoglobin biomarker: Nano-aptasensors approaches.

Acute myocardial infarction (AMI) is one of the main health problems, leading to a major rate of mortality and morbidity. Given that myoglobin (Mb) is the earliest rising biomarker after AMI, recent studies have shown that Mb may be considered as a suitable biomarker for the detection of cardiac damage. Recently, aptamer-based biosensors (aptasensors) have attracted special attention for being accessible and their capability for sensitive detection of Mb.

Recent Advances in the Fabrication of Nano-aptasensors for the Detection of Troponin as a Main Biomarker of Acute Myocardial Infarction.

Acute myocardial infarction (AMI) as the one of the main health threatening refers to reduced blood flow to the myocardium resulting in higher proportion of morbidity and mortality. Currently, cardiac troponin I (cTnI) and cardiac troponin T (cTnT) which have been regarded as the main specific AMI-related biomarkers which was predominant in AMI. Recently, aptamer-based biosensors or aptasensors have attracted special attention to accessible and sensitive detection of cardiac troponin.

Iranian centers of excellence in medical sciences: A qualitative study to analyze the current state and design of a future roadmap.

Due to the law for the fifth development plan and Iran's 20- year economic perspective, Centers of Excellence (COEs) were expected to upgrade the level of research and education besides improving infrastructures in Iran. This study is aimed to analyze the current state of national centers of excellence and designing a future roadmap. In this qualitative study, data was gathered by reviewing relevant national & international literature and upstream documents, interview with experts, and focused group discussions with stakeholders.

Immunogenicity of hepatitis B vaccine in multi-transfused thalassemic patients with and without hepatitis C infection: a comparative study with healthy controls.

Background: Hepatitis C virus (HCV) infection is highly prevalent in thalassemic patients. This may decrease serum antibody response to hepatitis B virus (HBV) vaccine. There is also some alteration in the immune system of multi-transfused thalassemic patients as a consequence of iron overload.