Estimation of 8-Hydroxy-deoxyguanosine (8-OHdG) in Saliva as a Marker of Oxidative Stress in Patients with Chronic Periodontitis: Preliminary Data.

Background: This preliminary study assesses the effects of initial periodontal treatment on salivary levels of 8-hydroxy-deoxyguanosine (8-OHdG) as a marker of oxidative stress in patients with chronic periodontitis (CP).

Methods: At baseline, clinical parameters and saliva samples were obtained from 20 patients with CP and 10 patients with clinically healthy periodontium. Saliva samples were collected, and clinical periodontal measurements were repeated at 2, 4, and 8 weeks after initial periodontal therapy in patients with CP.