What Dyadic Internet Street Fight Videos Can and Cannot Tell Us About the Ethological, Game Theoretic, and Sex-Differentiated Phenomenology of Human Physical Aggression.

Street fight videos on the internet may provide information about little known aspects of human physical aggression, but their reliability is unclear. Analyses of 100 dyadic fight videos addressing ethological, game theoretic and sex-differentiated questions derived from research on other animals found that prefight verbalizations or gestural signals of nonaggressive or aggressive intent loosely predicted who would strike first and who would win. The head is the preferred strike target.

Effects of Yersinia pseudotuberculosis outer membrane vesicles on Pseudomonas aeruginosa antigens immune response.

Outer membrane vesicles (OMVs) are immunogenic self-adjuvanting vesicles produced by Gram-negative bacteria such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis. While the effects of OMVs on different antigens immune stimulation are not clear. In this study, we constructed recombinant Yersinia pseudotuberculosis ΔlpxL strain,with pBlue-PcrV and pBlue-OprF/I, and then purified ΔlpxL rOMVPcrV (rOMVyp2P)and ΔlpxL rOMVOprF/I (rOMVyp2F) and analyzed its effect on immune response and protection against Pseudomonas aeruginosa PAO1 infection.

ssMutPA: single-sample mutation-based pathway analysis approach for cancer precision medicine.

Background: Single-sample pathway enrichment analysis is an effective approach for identifying cancer subtypes and pathway biomarkers, facilitating the development of precision medicine. However, the existing approaches focused on investigating the changes in gene expression levels but neglected somatic mutations, which play a crucial role in cancer development.

Findings: In this study, we proposed a novel single-sample mutation-based pathway analysis approach (ssMutPA) to infer individualized pathway activities by integrating somatic mutation data and the protein-protein interaction network.

[Molecular mechanisms of fresh Panax ginseng in treating myocardial ischemia based on FoxO signaling pathway].

Based on the differences in the protective effects of fresh Panax ginseng and its processed products on myocardial ischemia in mice, this study identified the advantageous aspects of fresh P. ginseng. By using network pharmacology combined with cell model validation, the molecular mechanisms of fresh P.

Differences in emergency hospitalization trauma patients during and after the COVID-19 pandemic.

Background: The spread of COVID-19 has a huge impact on the medical system, affecting the normal order of routine patients, especially obvious effect on the Shenzhen Third People's Hospital as the designated hospital for COVID-19 patients. After the epidemic was loosened in early December 2022, the normal medical order gradually restored in China. How much was the impact on the admission and treatment of emergency trauma patients during and after the epidemic? This study aims to compare the differences between trauma patients admitted to the emergency department during and after the COVID-19 pandemic.

Genome-Wide Transcriptional Profiling and Functional Analysis Reveal That OsPHT4;4 Is Critical for the Growth and Development of Rice.

Phosphorus (P) is an essential macronutrient required for various vital processes in crop growth and development, including signal transduction, CO fixation, and photosynthetic phosphorylation. Phosphate transporters (PHTs) in plants play critical roles in the uptake, distribution, and internal transport of Phosphate (Pi). Among these transporters, the PHT4 family is widely distributed across plant species; however, the specific functions of many members within this family remain to be fully elucidated.

Novel organophosphate esters and their transformation products in offshore sediment from Eastern China: Occurrence, temporal trend, and risk assessment.

Offshore sediment serves as an important sink for traditional organophosphate esters (TOPEs) originating from terrestrial sources. However, the contamination characteristics of novel OPEs (NOPEs) and their hydrolyzed and hydroxylated transformation products (Di- and OH-OPEs) in marine sediment are still unknown. In this study, 34 OPE-associated contaminants were measured in six offshore sediment cores (71 samples) collected from Eastern China.

Up-regulated fatty acid-binding protein 4 promoted cardiac injury during open colorectal surgery in elderly patients.

Background: Fatty acid binding protein 4 (FABP4) has been shown to increase cardiovascular disease. The FABP4 levels in serum and adipose tissue and the possible regulatory mechanisms during colorectal cancer surgery in elderly patients remain unknown.

Methods: Four hundred elderly patients with colorectal cancer were recruited, 200 underwent laparoscopic surgery (LS) and 200 underwent open surgery (OS).

Collaboratively removal of phosphate and glyphosate from wastewater by a macroscopic Zr-SA/Ce-UIO-66 adsorbent: Performance, mechanisms and applicability.

Dissolved inorganic and organic phosphorus is a major factor in triggering the eutrophication of water bodies. At present, a novel Zr cross-linked sodium alginate encapsulated in Ce-UIO-66 microspheres (Zr-SA/Ce-UIO-66) was prepared and systematically characterized. Its ability for capture of phosphate and glyphosate in their single and binary systems has been investigated comprehensively.

Giant molecule acceptors prepared by metal-free catalyzed reactions towards efficient organic solar cells.

Due to their defined structure and large molecular size, giant molecular acceptors (GMAs) have achieved significant progress in device efficiency and stability for organic solar cells. Unlike the classical synthesis of GMAs by Stille coupling, which still suffers from high cost and lack of environmental sustainability, this work develops three GMAs metal-free catalyzed reactions. By introducing varying quantities of malononitrile groups into the linker, the optoelectric properties of GMAs can be significantly regulated.

Bioinformatics Identification and Validation of Ferroptosis-Related Key Genes and Therapeutic Compounds in Septic Lung Injury.

Background: Septic lung injury (SLI) is a severe condition with high mortality, and ferroptosis, a form of programmed cell death, is implicated in its pathogenesis. However, the explicit mechanisms underlying this condition remain unclear. This study aimed to elucidate and validate key ferroptosis-related genes involved in the pathogenesis of SLI through bioinformatics analysis and experimental validation.

Steel Catenary Riser Fatigue Assessment: Fracture Mechanics Approach Versus - Curve Method.

In this paper, the fatigue resistance of a full-scale Steel Catenary Riser (SCR) girth weld is investigated using the Strength-Number of cycles (-) curve method based on weld formation quality and fracture mechanics approaches. The test results, presented in the form of - curves, are superior to the design curve E in BS 7608. Compared with the - curve determined by a resonant bending rig, the analytical fracture mechanics, i.

MethylGPT: a foundation model for the DNA methylome.

DNA methylation serves as a powerful biomarker for disease diagnosis and biological age assessment. However, current analytical approaches often rely on linear models that cannot capture the complex, context-dependent nature of methylation regulation. Here we present MethylGPT, a transformer-based foundation model trained on 226,555 (154,063 after QC and deduplication) human methylation profiles spanning diverse tissue types from 5,281 datasets, curated 49,156 CpG sites, and 7.

A novel demodulation method of the channeled modulated polarization imaging pictures by hybrid feature modulated autoencoders.

Channeled modulated polarization imaging technology offers advantages owing to its simple structure and low cost. However, the loss of high-frequency information due to channel crosstalk and the filter demodulation method has consistently hindered the mature application of this technology. We analyzed the data structure of pictures detected using this technology and proposed a demodulation method using hybrid feature modulated autoencoders.

Identification of Active Ingredients in Ginseng Volatile Oil: A Strategy Combining Computer Virtual Screening With Experimental Validation.

Background: Ginseng volatile oil (GVO) is a valuable active ingredient in ginseng (Panax ginseng C. A. Mey.

Different paths, same destination: Bisphenol A and its substitute induce the conjugative transfer of antibiotic resistance genes.

Antibiotic resistance genes are primarily spread through horizontal gene transfer in aquatic environments. Bisphenols, which are widely used in industry, are pervasive contaminants in such environments. This study investigated how environmentally relevant concentrations of bisphenol A and its substitute (bisphenol S, Bisphenol AP and Bisphenol AF) affect the spread of antibiotic resistance genes among Escherichia coli.

Correlation of metabolic markers and OPG gene mutations with bone mass abnormalities in postmenopausal women.

Objective: The aim was to investigate the relationship between metabolic indices and abnormal bone mass (ABM), analyse the association between osteoprotegerin (OPG) gene mutations and ABM, and explore the interaction effect of type 2 diabetes mellitus (T2DM) and OPG gene mutations on bone mineral density (BMD) in postmenopausal women to provide a new supplementary index and a reliable basis for the early identification of osteoporosis (OP) in postmenopausal women in the clinical setting.

Methods: Postmenopausal women hospitalized within the Department of Endocrinology of the First Affiliated Sanatorium of Shihezi University from June 2021 to March 2023 were retrospectively analysed, and the bone mineral density of lumbar vertebrae 1-4 (BMD (L1-4)) of the studied subjects was measured once via twin-energy X-ray absorptiometry. The studied subjects were divided into a normal bone mass (NBM) group and an ABM group according to their bone mineral density, and the general data of the studied subjects were recorded once.

Machine Learning Models for Predicting Bioavailability of Traditional and Emerging Aromatic Contaminants in Plant Roots.

To predict the behavior of aromatic contaminants (ACs) in complex soil-plant systems, this study developed machine learning (ML) models to estimate the root concentration factor (RCF) of both traditional (e.g., polycyclic aromatic hydrocarbons, polychlorinated biphenyls) and emerging ACs (e.

Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma.

Epithelial ovarian carcinoma (EOC) is the most fatal among female reproductive system tumors. The immune tumor microenvironment and ubiquitin-proteasome pathway are closely related to the proliferation, invasion, and response to chemotherapy in EOC. However, their specific roles in EOC have not been fully elucidated.