Proteomic Analysis of Mesenchymal Stem Cell-derived Exosomes in Psoriasis.

Purpose: This study aims to investigate the unique proteins in exosomes from mesenchymal stem cells derived from psoriatic lesions and compare them with those from healthy human skin. It seeks to identify potential regulatory factors that may influence the differential effects observed in these exosomes.

Methods: Dermal mesenchymal stem cell exosomes were isolated from healthy human skin (HDMSCs-EXO) and psoriatic lesion of patient (PDMSCs-EXO).

Early Alpha-Fetoprotein Response Predicts Sustained Tumor Response Following Immune Checkpoint Inhibitors Combined with Targeted Therapy in Liver Cancer.

Although immune checkpoint inhibitors (ICI) have revolutionized liver cancer treatment, some patients experience early tumor progression after therapy, missing the window for other potential treatments, such as neoadjuvant therapy. Therefore, identifying the predictive factors for early progression is critical for timely therapeutic adjustment and the optimization of patient outcomes. This retrospective study enrolled patients with liver cancer who received their first ICI combined with targeted therapy at the Fifth Medical Center of the PLA General Hospital between June 2022 and December 2023.

The Response Mechanism of the cbbM Carbon Sequestration Microbial Community in the Alpine Wetlands of Qinghai Lake to Changes in Precipitation.

The dramatic changes in precipitation patterns on the Tibetan Plateau affected the carbon-sequestering microbial communities within wetland ecosystems, which were closely related to the responses and adaptation mechanisms of alpine wetland ecosystems to climate change. This study focused on wetland soils subjected to different precipitation gradient treatments and employed high-throughput sequencing technology to analyze the soil cbbM carbon-sequestering microbial communities. The results indicated that Proteobacteria were the dominant microbial community responsible for carbon sequestration in the Wayan Mountain wetland.

Challenge-Hindrance Stressors and Novice Nurses' Safety Behaviour: The Mediating Role of Regulatory Focus and the Moderating Role of Workplace Spirituality.

Aims: This study aims to investigate the impact of challenge-hindrance stressors on novice nurses' safety behaviour, the mediating effect of regulatory focus, and the moderating effect of workplace spirituality.

Background: The relationship between challenge-hindrance stressors and novice nurses' safety behaviour has rarely been investigated, despite the global concern for patient safety in healthcare systems. Previous research suggests that regulatory focus and workplace spirituality matter for nurse safety behaviour, but the relationship between them remains unclear.

Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive.

Background: Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also presented in non-PBC individuals.

Methods: A total of 72173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals.

Prevalence and influencing factors of skin tears in older adults: A systematic review and meta-analysis.

Objective: To systematically evaluate the prevalence and influencing factors of skin tears in older adults.

Methods: The Cochrane Library, Web of Science, Embase, PubMed, CNKI, VIP, WanFang Data, and CBM databases were searched to collect studies related to the prevalence and influencing factors of skin tears in older adults, and the search period was from inception to October 29, 2024. The examined literature was independently screened, data extracted, and evaluated for risk of bias, and the meta-analysis was performed using Stata17.

Mitigation of irreversible membrane biofouling by CNTs-PVDF conductive composite membrane.

Biofouling has been one of the major challenges impacting the long-term stable operation of ultrafiltration processes. Irreversible biofouling is considerably more harmful than reversible biofouling. Conductive membrane, as a new technology to effectively mitigate membrane fouling, lack research of controlling irreversible biofouling.

Heterogeneous blood pressure treatment effects on cognitive decline in type 2 diabetes: A machine learning analysis of a randomized clinical trial.

Aim: We aimed to identify the characteristics of patients with diabetes who can derive cognitive benefits from intensive blood pressure (BP) treatment using machine learning methods.

Materials And Methods: Using data from the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) study, 1349 patients with type 2 diabetes who underwent BP treatment (intensive treatment targeting a systolic BP <120 mmHg vs. standard treatment targeting <140 mmHg) were included in the machine learning analysis.

[Progress in the Application of Biochar in Constructed Wetland].

Constructed wetlands, serving as artificially simulated natural wetland water treatment systems, have emerged as effective technologies for ecologically treating wastewater. Biochar, a carbon material derived from biomass waste pyrolysis, possesses significant specific surface area, abundant functional groups, and high stability. The integration of biochar into artificial wetland systems enhances the removal efficiency of pollutants.

Development and evaluation of pH-sensitive Euryale ferox starch-based films containing nano-SiO and Chinese rose (Rosa chinensis) extract for freshness monitoring of chicken breast meat.

In this study, smart films of EFS, EFS-SiO and EFS-SiO-CRE were successfully developed by using Euryale ferox starch (EFS), nano-SiO and Chinese rose extract (CRE). The Chinese rose flower had a high content of anthocyanins (1.73 mg/g) and CRE exhibited different colors in varying pH buffers (2-13).

[Widely targeted metabolomics reveals differences of secondary metabolites in rhizomes of different Coptis species].

To deeply understand the chemical components and functional differences of the rhizomes from different Coptis species, this study employed widely targeted metabolomics for the metabolic profiling of C. chinensis, C. deltoidea, and C.

FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions.

Introduction: Altered epigenetic reprogramming enables breast cancer cells to adapt to hypoxic stress. Hypoxic microenvironment can alter immune cell infiltration and function, limiting the effectiveness of immunotherapy.

Objectives: The study aimed to identify how fat mass and obesity-associated protein (FTO) helps breast cancer cells cope with the hypoxic microenvironment and the mechanisms behind breast cancer cell resistance to tumor immunity.

Mineral and Microbial Properties Drive the Formation of Mineral-Associated Organic Matter and Its Response to Increased Temperature.

A comprehensive understanding of the formation of mineral-associated organic matter (MAOM) is a prerequisite for the sustainable management of soil carbon (C) and the development of effective long-term strategies for C sequestration in soils. Nevertheless, the precise manner by which microbial and mineral properties drive MAOM formation efficiency and its subsequent response to elevated temperature at the regional scale remains unclear. Here, we employed isotopically labelled laboratory incubations (at 15°C and 25°C) with soil samples from a ~3000 km transect across the Tibetan Plateau to elucidate the mechanisms underlying MAOM formation and its temperature response.

Rapid, multiplex and automated detection of bacteria and fungi in endophthalmitis via a microfluidic real-time pcr system.

Background: Endophthalmitis is an ophthalmologic emergency requiring accurate and rapid diagnosis for treatment. Currently, the diagnosis commonly relies on culture and molecular biology, which falls short of clinical rapid diagnosis. The purpose of this study was to evaluate the feasibility of a self-build Microfluidic Real-time Polymerase Chain Reaction (RT-PCR) System for rapidly identifying potential pathogens of endophthalmitis.

Causal relationship between 41 inflammatory factors, circulating white blood cells, and pruritus: A 2-sample bidirectional Mendelian randomization study.

The influence of circulating white blood cells and inflammatory factors on pruritus is gradually recognized by the public, but the specific causal relationship is still unknown. In this study, we included inflammatory cytokine profiles from 8293 healthy subjects, genetic data on blood cells from various ethnic and ancestry backgrounds, including 746,667 individuals, and 1370 patients of European descent with pruritus for a bidirectional 2-sample Mendelian randomization (MR) analysis. We employed several robust statistical methods, including the inverse variance weighted, weighted median, and the MR-Egger method.

Motion Planning and Control with Environmental Uncertainties for Humanoid Robot.

Humanoid robots are typically designed for static environments, but real-world applications demand robust performance under dynamic, uncertain conditions. This paper introduces a perceptive motion planning and control algorithm that enables humanoid robots to navigate and operate effectively in environments with unpredictable kinematic and dynamic disturbances. The proposed algorithm ensures synchronized multi-limb motion while maintaining dynamic balance, utilizing real-time feedback from force, torque, and inertia sensors.

Preparation of Functional Food with Enhanced Antioxidant Properties by Adding Polyphenol Honey.

To enhance the functionality of honey, particularly its antioxidant capacity, the incorporation of polyphenols (AMPs) is an effective approach. The preparation technology and antioxidant activity of AMP added to honey were studied. AMP was extracted with ethanol and its components were analyzed and then mixed evenly with honey in different addition amounts (0.

Promise of the gut microbiota in prevention and traditional Chinese medicine treatment of diabetic peripheral neuropathy.

The pathogenesis of diabetic peripheral neuropathy (DPN) has not been fully elucidated, and treatment options are limited. Currently, the main strategies for treating DPN are strict glycemic control and symptomatic pain relief. In this editorial, we comment on an article by Li which suggested that modulating the gut microbiota using traditional Chinese medicine (TCM) may be a promising strategy for alleviating DPN symptoms.

Research on the Structural and Magnetic Phase Transitions of CeMnGe Alloy.

Magnetic phase transitions play crucial roles in various material applications, including sensors, actuators, information storage, magnetic refrigeration, and so on. Typically, these magnetic phase transitions exhibit discontinuous first-order phase transitions. When a material undergoes a magnetic phase transition, it often exhibits simultaneous changes in both its crystal and electronic structures.

Hypo-osmolarity promotes naive pluripotency by reshaping cytoskeleton and increasing chromatin accessibility.

Introduction: Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear.

Transcriptomic analysis of regulatory mechanisms in the telogen-anagen transition of ovine hair follicles.

Background: Dorper sheep are celebrated for their fast maturation and superior meat quality, with some shedding their wool each spring. Wool shedding occurs naturally due to the hair follicle (HF) cycle, but its regulatory mechanisms remain unclear and need further investigation.

Results: In this study, shedding and non-shedding sheep were selected from the same Dorper flock.