Publications by authors named "Si-min Luo"

Objective: Charcot arthropathy is characterized by varying degrees of sensory loss and rapidly progressive joint destruction. Historically, limited studies indicated that Charcot arthropathy of the hip joint may be a contraindication for total hip arthroplasty (THA). Yet, some recent studies have shown that good clinical results and acceptable survival rate.

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  • Renal fibrosis (RF) is the final stage of chronic kidney diseases, characterized by an accumulation of extracellular matrix and changes that lead to kidney dysfunction or failure.
  • Traditional Chinese medicine (TCM) shows promise in treating RF through natural products that target specific pathways and processes involved in the disease, potentially reversing or slowing its progression.
  • Nanodrug delivery systems are being researched to enhance the effectiveness of these natural products, addressing issues like low oral bioavailability, and offering new avenues for RF treatment.
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Background: Both closed platform and open platform robotic-assisted total hip arthroplasty (THA) have recently been recommended as a viable treatment option for achieving accurate positioning of components. Yet, limited studies paid attention to the differences between the closed platform robotic system and the open platform robotic system. Hence, this study aimed to investigate clinical outcomes, radiographic outcomes, complication rates and learning curve of two systems.

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Background: Patients with poliomyelitis underwent total hip arthroplasty (THA) are known to be at higher risk of dislocation on account of muscular atrophy. This study aimed to investigate clinical outcomes, radiographic outcomes, complication rates, and survivorship of dual mobility THA in displaced femoral neck fractures of elderly with poliomyelitis.

Materials And Methods: We retrospectively included 17 patients (17 hips) with residual poliomyelitis who underwent THA with dual mobility articulation.

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Background: Performing postoperative laboratory tests following joint arthroplasty is a regular practice. However, the role of routine postoperative laboratory tests in primary hip arthroplasty is currently in doubt. This study aimed to assess the role of routine postoperative laboratory tests for femoral neck fractures in elderly patients who underwent hip hemiarthroplasty and to evaluate the risk factors for postoperative laboratory testing abnormalities and related interventions.

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  • The study aimed to create a diabetes-osteoarthritis (DM-OA) mouse model to confirm that diabetes worsens osteoarthritis and investigate the impact on subchondral bone properties.
  • Mice were divided into three groups (DM-OA, OA, and sham), with assessments of blood glucose, body weight, food intake, and various biochemical markers for bone metabolism.
  • Results showed that the DM-OA group had elevated markers of bone turnover, altered calcium and osteocalcin levels, and significant deterioration in bone structure and strength compared to the other groups.
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As a representative foreign medicinal material, olibanum(Ruxiang) was imported to China since the Qin and Han Dynasties. Olibanum was first described as a medicinal by the name "Xunluxiang" in Miscellaneous Records of Famous Physicians(Ming Yi Bie Lu). This study investigated historical records on olibanum and conducted the herbalogical study.

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Citri Sarcodactylis Fructus is a both medicinal and edible species specified by the China Ministry of Health, with a long history in China. According to the ancient monographs about materia medica, it was found that the records of the Citri Sarcodactylis Fructus on the original plants were confused. This paper reviewed the ancient monographs about materia medica, and made a summarization and textual research on the name, origin, habitat, processing methods, medicinal properties and clinicacy efficacy of Citri Sarcodactylis Fructus based the comprehensive analysis on modern literatures and authoritative books of Chinese herbal medicine.

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Background: Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of affected the expression of 256 downstream transcripts and increased the metastatic potential of colon cancer cells in vitro and in vivo.

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Coicis Semen is widely used as a raw material which can be used as both medicine and food among people. According to the ancient monographs on materia medica and relevant documents on the processing specifications in various provinces and cities, herba logical study on the historical evolution of the processing methods of Coicis Semen was conducted in this paper from the aspects of collecting and processing methods of Coicis Semen, the processing methods in the past dynasties and the nature, flavour and efficacy of Coicis Semen. The results showed that the processing methods of Coicis Semen recorded in monographs on materia medica mainly included stir-frying, glutinous rice stir-frying, salt processing(including salt cooking and salt stir-frying), stir-frying with the earth scraped from the wall facing east, and ginger juice stir-frying, etc.

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Introduction: Internal fixation (IF) with cannulated screws is the most widely accepted operation method for nondisplaced femoral neck fractures (FNFs) in elderly patients. However, there were higher rate of reoperation, severe complications and poorer functional outcomes reported in these patients treated with IF. The purpose of this research is to compare the prognosis, complications, reoperation and mortality of bipolar hemiarthroplasty (HA) with IF of cannulated screws in elderly patients.

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Integrin β1 is known to be involved in differentiation, migration, proliferation, wound repair, tissue development, and organogenesis. In order to analyze the binding probability between integrin β1 ligand and cluster of differentiation 29 (CD29) receptors, atomic force microscopy (AFM) was used to detect native integrin β1-coupled receptors on the surface of human adipose-derived stem cells (hADSc). The binding probability of integrin β1 ligand-receptor interaction was probed by integrin β1-functionalized tips on hADSc during early chondrogenic differentiation at the two-dimensional cell culture level.

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Objective: To explored the relationship between the concentration of potassium ion as well as sodium ion in the aqueous humor and post-mortem interval (PMI).

Methods: The concentrations of potassium ion and sodium ion in the aqueous humor of swine within 48 h after death at 4 degrees C and 28 degrees C were detected using Z-500 atomic absorption spectrophotometer.

Results: The concentrations of potassium ion and sodium ion in aqueous humor of isolated swine eyeballs within 48 h after death when the environmental temperature was 4 degrees C were significantly related to PMI.

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Objective: To investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.

Methods: The expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.

Results: The expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues (P<0.

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Objective: To study the characteristic of endothelial injuries and the mechanisms of coagulation disorder in multiple organ dysfunction syndrome in elderly rats by observing the distribution and the intensity of fibronectin (FN) expression in important viscerae including the heart, brain, lung, kidney, liver.

Methods: Fifty Wistar rats (one half of them were 3 months old, another half 20 months old) were anaesthetized and cecal ligation puncture (CLP) was done. They were defined as MODS group and MODSE group.

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Objective: To study the expression of thrombomodulin (TM) and its significance in the pathogenesis of multiple organs dysfunction syndrome (MODS).

Methods: TM expression was determined by immunohistochemical staining in 20 autopsy cases with MODS group and 12 autopsy cases without MODS (control group).

Results: Significant differences in positive expression of TM in heart, lungs and kidneys were found between the control group and MODS group (all P<0.

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