[Relationship between plasma glucose level and insulin secretion in type 2 diabetic patients].

Objective: To investigate the association between insulin secretion and plasma glucose levels, and the potential effect of plasma glucose concentration on insulin secretion stimulated by glucose in patients with type 2 diabetes.

Methods: A total of 124 patients with type 2 diabetes were enrolled to undergo 75 g oral glucose tolerance test (OGTT) and insulin releasing test (IRT), 24 h after discontinuation of oral hypoglycemic agent or insulin injection. The plasma levels of glucose and insulin, effects of fasting and postprandial plasma levels of glucose and insulin, the time of maximal glucose value in OGTT, the ratio of maximal to basal glucose levels (M/Bg) were determined to assess their effects on the basal and stimulated insulin secretion.