Publications by authors named "Si-cong Lu"
Hepatocellular carcinoma (HCC) is one of the most prevalent and life-threatening malignancies worldwide. There are few diagnostic and prognostic biomarkers and druggable targets for HCC. Aldehyde dehydrogenase 1 (ALDH1) is a marker of stem cells in a variety of cancers, but the mRNA levels and prognostic value of ALDH1 isoforms in HCC patients remain unknown.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the relationship between the expression of the MKI67 proliferation marker and gene variants in patients with Hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV).
- Researchers analyzed data from 195 HCC patients and validated findings with 97 additional subjects, examining connections between MKI67, gene variants, and clinical outcomes.
- Results showed that certain genetic variants near the TTN and CCDC8 genes are linked to MKI67 expression and could serve as potential biomarkers for predicting HCC patient prognosis.
Objective: To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development.
Design: Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC.
Data Sources: EMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case-control studies of COX-2 polymorphism and HCC risk.
Objective: To study the effect of total body irradiation of the donor in a spontaneous tolerance rat liver transplantation model and the role of CD4(+)CD25(+) regulatory T cells on induction of immunotolerance in the recipient.
Methods: Liver transplantation was performed using male Lewis rats as donors and male DA rats as recipients. These rats were randomly allocated into the following groups:Control group, Homogeneity Liver Transplantation group, Idio-immunotolerance group and Acute Rejection group.