Publications by authors named "Si-Zheng Wang"
Article Synopsis
- The study aimed to understand how methotrexate (MTX) is processed in children with acute lymphoblastic leukemia (ALL) by examining its delayed excretion patterns.
- Researchers analyzed 1,659 plasma samples from 190 patients, using specific software to assess various factors that might affect MTX levels, such as age and body size.
- The findings revealed a two-compartment model that accurately describes MTX clearance and distribution, indicating that body surface area significantly influences its clearance rate in these patients.