Publications by authors named "Si-Ying Zhang"
Background: Few studies have investigated the associations of childhood growth trajectories with the prenatal metabolic risks of mothers and their interaction with children's genetic susceptibility.
Objective: To investigate the effects of gestational metabolic syndrome (GMS) risks and children's polygenic risk scores (PRSs), and their interaction effect on the BMI trajectory and obesity risk of offspring from birth to 6 years of age.
Methods: A total of 2,603 mother-child pairs were recruited from the Ma'anshan birth cohort (Anhui Province of China) study.
Article Synopsis
- The study examined the effects of prenatal exposure to phthalates on placental structure and function, utilizing data from 2,723 women in the Ma'anshan Birth Cohort.
- It found significant relationships between various phthalate metabolites and placental weight, efficiency, and chorionic disc area across all trimesters, with some showing inverted U-shaped nonlinear trends.
- However, combined exposure to multiple phthalate metabolites did not correlate with any placental measures, suggesting that individual phthalates have more impact than their mixtures.
Background: Poor prognosis of digestive system cancers is mainly owing to lack of accurate and timely diagnosis. The exploration of novel tumor biomarkers from extracellular vesicle (EV) might be helpful to clinical diagnosis for digestive system cancers.
Methods: Several public databases were first used for a preliminary screening of candidate genes.
When individuals in social groups communicate with one another and are under the influence of neighbors' opinions, they typically revise their own opinions to adapt to such peer opinions. The individual threshold of bounded confidence will thus be affected by both a change in individual confidence and by neighbor influence. Individuals thus update their own opinions with new bounded confidence, while their updated opinions also influence their neighbors' opinions.
View Article and Find Full Text PDFObjective: To analyze serum vancomycin concentration after administration of different therapeutic doses in children with Staphylococcus aureus pneumonia (SAP) in order to determine the appropriate dose of vancomycin in clinical administration.
Methods: The clinical data of 35 children who were diagnosed with SAP and treated with vancomycin from January 2008 to December 2013 were retrospectively analyzed.
Results: Among the 35 SAP cases with vancomycin therapy, 22 cases (63%) had serum vancomycin trough concentration monitored.
Objective: To compare the clinical manifestations between inhaled and blood-borne Staphylococcus aureus pneumonia (SAP) and the antibiotic resistance between the isolates of inhaled and blood-borne Staphylococcus aureus.
Methods: The clinical data of 44 pediatric SAP cases in the Children′s Hospital, Chongqing Medical University from January 2008 to December 2013 were retrospectively analyzed. Twenty-four cases were identified as inhaled SAP, and 20 cases as blood-borne SAP.
[The effect of human placenta-derived mesenchymal stem cells on cord blood CD8(+);T cells activation, cellcycle and secretion of IL-17].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2012
Article Synopsis
- The study investigates how human placenta-derived mesenchymal stem cells (hPMSCs) affect the activation and cytokine secretion of CD8(+) T cells from cord blood.
- Researchers isolated and cultured hPMSCs, then analyzed CD8(+) T cells using specific techniques to measure their activation and cell cycle.
- Results show that hPMSCs inhibit the activation of CD8(+) T cells while increasing their secretion of IL-17, suggesting potential applications in cell-based therapies.