Publications by authors named "Si-Yi Wei"
Colorectal cancer (CRC) is characterized by a highly immunosuppressive tumor microenvironment, which limits the effectiveness of current immunotherapies. Identifying strategies to overcome this resistance is critical for improving treatment outcomes. In this study, we discovered that USP19 plays a pivotal role in regulating T-cell-mediated antitumor immunity through a CRISPR/Cas9 sgRNA library screen and co-culture assays with activated T cells.
View Article and Find Full Text PDFCurcumin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.
Mol Nutr Food Res
October 2024
Scope: Curcumin (Cur), with diverse pharmacological properties, shows anti-obesity, immunomodulatory, and anti-inflammatory effects. Its role in ulcerative colitis complicated by obesity remains unclear.
Methods And Results: Here, colitis is induced in obese mice using dextran sulfate sodium (DSS), followed by administration of Cur at a dosage of 100 mg kg for 14 days.
Article Synopsis
- PCOS is a common endocrine disorder in women of reproductive age and our study investigates the pregnancy outcomes of embryo transfers in women with this condition, particularly focusing on the impact of high androgen levels on endometrial receptivity.
- A retrospective study involving 2714 infertile women and 452 women with PCOS found that pregnancy outcomes, including implantation and live birth rates, were significantly lower in women with PCOS after fresh embryo transfers, despite pretreatment.
- The research indicates that higher testosterone levels on the day of embryo transfer negatively affect pregnancy rates and the expression of important endometrial markers, suggesting that even with treatment, endometrial receptivity remains impaired in women with PCOS.
Article Synopsis
- Immune dysfunction plays a key role in inflammatory bowel disease (IBD), particularly involving various types of immune cells like B and T lymphocytes, and their imbalance can lead to autoimmune diseases such as IBD.
- The study aimed to determine if curcumin (Cur) could help reduce symptoms of experimental colitis by affecting memory B cells and related signaling pathways.
- The results showed that after 14 days of Cur treatment, mice with colitis experienced improvements in their physical condition and decreased pro-inflammatory cytokines, along with changes in the activation levels of memory B cell subsets.
The rising incidence of ulcerative colitis has become a new challenge for public health. Oliv. leaf granule (COG) is a natural medicine used for the treatment of respiratory diseases, which has excellent anti-inflammatory and antioxidant effects.
View Article and Find Full Text PDFDiabetes mellitus (DM) is one of the most common complications in patients with ulcerative colitis (UC). Curcumin has a wide range of bioactive and pharmacological properties and is commonly used as an adjunct to the treatment of UC and DM. However, the role of curcumin in UC complicated by DM has not been elucidated.
View Article and Find Full Text PDF