Publications by authors named "Si-Ye Chen"
Article Synopsis
- The study investigated the combination of deep inspiratory breath-hold (DIBH) and volumetric modulated arc therapy (VMAT) for enhancing dosimetric outcomes in left-sided postmastectomy radiotherapy (PMRT) for breast cancer patients.
- Results showed that DIBH significantly reduced radiation doses to the heart, left anterior descending artery (LAD), and left lung compared to free breathing (FB), ensuring better cardiopulmonary protection regardless of whether internal mammary node irradiation (IMNI) was included.
- The treatment's setup was highly precise, with setup errors of less than 0.3 cm and overall planning target volume margins under 1.0 cm
Article Synopsis
- The study looked at how the number of white blood cells (lymphocytes) in breast cancer patients might affect their chances of surviving after surgery and radiation treatment.
- Researchers found that many patients had a drop in lymphocyte counts during treatment, but it was mostly not too severe.
- Lower lymphocyte counts before treatment were linked to lower survival rates, suggesting that checking these counts could help doctors understand a patient's prognosis better.
This study was to report proxy measures for mortality risk in patients with hematological malignancies across 185 countries globally and explore its association with their socioeconomic status and treatment. The incidence, mortality, and 5-year prevalence data were extracted from the GLOBOCAN database. The data regarding the human development index (HDI), gross national income (GNI), vulnerability index, and concordance with cancer Essential Medicines List (EML) were obtained from open-source reports.
View Article and Find Full Text PDFTo investigate the dosimetric advantages of the voluntary deep inspiration breath-hold technique assisted by optical surface monitoring system for whole breast irradiation in left breast cancer after breast-conserving surgery and verify the reproducibility and acceptability of this technique. Twenty patients with left breast cancer receiving whole breast irradiation after breast-conserving surgery were enrolled in this prospective phase II study. Computed tomography simulation was performed during both free breathing and voluntary deep inspiration breath-hold for all patients.
View Article and Find Full Text PDFArticle Synopsis
- Recently, a new metric called progression-free survival at 24 months (PFS24) was established as a key indicator for predicting outcomes in patients with extranodal NK/T cell lymphoma.
- Analysis was conducted using data from two separate groups of 696 patients each to create and validate a risk index (PFS24-RI), which can forecast early disease progression.
- The PFS24-RI identified five significant risk factors and categorized patients into low, intermediate, and high-risk groups, showing strong predictive ability for both progression and overall survival outcomes.
Background: Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It's important to assess the value of multi-modal MRI-based radiomics for estimating overall survival (OS) in patients with ENKTCL.
Methods: Patients with ENKTCL in a prospectively cohort were systemically reviewed and all the pretreatment MRI were acquisitioned.
Purpose: The aim of this study is to evaluate the role of regional nodal irradiation (RNI) in patients with T1-2N1M0 breast cancer and to identify the subgroup that could benefit from RNI.
Methods And Materials: A total of 4,243 women with pT1-2N1M0 breast cancer treated at two institutions in China were retrospectively reviewed. Survival rates were calculated by the Kaplan-Meier method and compared by the log-rank test.
Purpose: To investigate the appropriate timing of radiotherapy (RT) after mastectomy and adjuvant chemotherapy for women with high-risk breast cancer.
Patients And Methods: Post hoc analyses of 584 patients with stage II and III breast cancer from a randomised controlled clinical trial were performed. All patients underwent mastectomy followed by sequential chemotherapy and RT.
Article Synopsis
- Early-stage MALT lymphoma patients have a lower risk of dying from lymphoma compared to other causes, highlighting the importance of age in treatment outcomes.
- An analysis of 9,467 patients showed that radiotherapy significantly improved overall survival (73.8%) and relative survival compared to chemotherapy and other treatments.
- The study found that younger adults benefited more from radiotherapy, indicating a notable interaction between age and treatment effectiveness.
Background And Purpose: We investigated the locoregional effect of trastuzumab, and determined whether patients with human epidermal growth factor receptor (HER)2-positive breast cancer (BC) treated with trastuzumab could achieve comparable efficacy to that of patients with HER2-negative BC.
Materials And Methods: This was analyses of data of 793 BC patients from a randomized controlled trial comparing post-mastectomy hypofractionated radiotherapy with conventional fractionated radiotherapy. Survival rates were analyzed by the Kaplan-Meier method and compared by the log-rank test.
Background: To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1-2N1M0 breast cancer.
Methods: A total of 4262 women with T1-2N1M0 breast cancer treated at two institutions were retrospectively reviewed. A total of 3858 patients underwent MRM, and 832 (21.
Purpose: To investigate the effect of chemotherapy and radiotherapy timing after breast conserving surgery (BCS) on recurrence and survival of women with early-stage breast cancer.
Patients And Methods: We retrospectively analyzed 900 patients who underwent BCS followed by both adjuvant chemotherapy and radiotherapy. Of these, 488 women received chemotherapy first (CT-first group) while the other 412 received radiotherapy first (RT-first group).
Background: Liver cancer is a devastating disease that has second highest cancer mortality rate worldwide. Although surgical resection or liver transplantation sometimes cures early stage liver cancer, few therapeutic options are available for advanced-stage liver cancer, highlighting the importance of a better understanding of the disease to find novel therapeutic targets.
Methods: Firstly, clinical features of EPS8L3 on liver cancer RNA-seq dataset of The Cancer Genome Atlas (TCGA) database was analyzed, including gene expression levels in tumor tissues in comparison with the normal tissues as well as the patients' OS.
Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracycline-based chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3- and 5-year OS in the validation cohort. The Harrell's C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK.
View Article and Find Full Text PDF[Effects of short-term continuous shear stress on cells growth and recovery of Laminaria japonica gametophytic cells in photobioreactor].
Sheng Wu Gong Cheng Xue Bao
September 2007
Laminaria japonica gametophytic cells were cultivated in a photobioreactor under continuous shear stress (0-1000 r/min) in 60 hours and the following static cultivation within 23.5 days. The content of chlorophyll a reached the maximum value of 2.
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