Publications by authors named "Si-Xing Bi"
Xanthatin is a natural sesquiterpene lactone purified from Xanthium strumarium L., which has shown prominent antitumor activity against a variety of cancer cells. In the current study, we investigated the effect of xanthatin on the growth of glioma cells in vitro and in vivo, and elucidated the underlying mechanisms.
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- The study investigates xanthatin's effects on glioma growth using nude mouse and rat models, monitored via MRI.
- Xanthatin at 0.4 mg/10 g significantly reduced tumor growth in nude mice, while doses of 8 and 16 mg/kg showed antiangiogenesis by lowering vessel permeability (K value).
- The findings indicate xanthatin inhibits C6 glioma through antiangiogenesis and highlight the usefulness of DCE-MRI in evaluating tumor growth and angiogenesis in research.
As an endoplasmic reticulum (ER) stress-inducible protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) has been proven to protect dopaminergic neurons and nondopaminergic cells. Our previous studies had shown that MANF protected against ischemia/reperfusion injury. Here, we developed a magnetic resonance imaging (MRI) technology to dynamically evaluate the therapeutic effects of MANF on ischemia/reperfusion injury.
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