Publications by authors named "Si-Wei Xia"
Article Synopsis
- - Endoplasmic reticulum (ER) stress in chronic liver disease leads to the accumulation of misfolded proteins, triggering an unfolded protein response (UPR) that regulates protein degradation systems like the ubiquitin-proteasome system (UPS) and autophagy.
- - UPR activates various transcription factors that enhance the expression of genes related to UPS and autophagy, helping cells cope with ER stress and preventing cell death (apoptosis).
- - Understanding the role of protein degradation in chronic liver diseases (like NAFLD and HCC) opens up potential treatment strategies, where either promoting or inhibiting this process may be beneficial for patients.
Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis, characterized by enhanced retinoic acid signals. Although up-regulated retinoic acid signal responds further to maintain HSC activation, the underlying molecular mechanisms are largely unknown. In this study, we sought to investigate the role of lncRNA-H19 in regulation of retinoic acid signals, and to further examine the underlying mechanism in this molecular context.
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