Publications by authors named "Si-Wei He"
IL-6 alters migration capacity of CD4Foxp3 regulatory T cells in systemic lupus erythematosus.
Scand J Immunol
November 2021
Article Synopsis
- - The study investigates the dysfunction of regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) to better understand their impaired chemotaxis amid inflammation.
- - Researchers found that Tregs in SLE patients had decreased expression of certain chemokine receptors (CCR4 and CCR6), while non-Treg CD4 T cells showed increased expression of CCR4 and heightened chemotactic response to its ligands.
- - The cytokines IL-6 and IL-10 were shown to influence the receptor expression, with IL-6 elevating non-Treg CD4 T cells' CCR4 and CCR6, but Tregs produced more IL-10, which inhibited these receptors and limited their ability
It was demonstrated that Sphingosine kinase 1 (SphK1) promotes tumor progression and confers the malignancy phenotype of colorectal cancer by activating the focal adhesion kinase (FAK) pathway. However, further clarification is required to determine if SphK1 promotes the metastasis of colorectal cancer by inducing epithelial‑mesenchymal transition (EMT), and its mechanisms have not been fully elucidated. Immunohistochemistry staining was used to detect protein expression in normal colonic mucosa tissues and colorectal cancer tissues.
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