Importance of Binding Affinity for the Activity of a Metallodendritic Chemical Nuclease.

A family of (2-pyridyl)amino-modified poly(amidoamine) dendrimer Cu complexes was prepared, and their chemical nuclease activities and binding affinity () levels for DNA plasmid were investigated. The values of the G2 to G6 apodendrimers for DNA plasmid were found to be 7.4, 23, 48, 70, and 280 µM, respectively, using ethidium bromide (EtBr) displacement experiments.