CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis.

Background: The contribution of B-cell subsets and T-B cell interaction to the pathogenesis of allergic rhinitis (AR) and mechanisms of allergen immunotherapy (AIT) remain poorly understood. This study aimed to outline circulating B-cell signature, the underlying mechanism, and its association with clinical response to AIT in patients with AR.

Methods: IgD/CD27 and CD24/CD38 core gating systems were used to determine frequencies and phenotypes of B cells.