Reproductive behaviour and longevity: Evidence from Chinese centenarians.

With the implementation of the three-child policy in China, the debate between fertility and health and longevity has again become a hot topic in the era of increasing ageing. This study aimed to explore the association between reproductive behaviour and longevity of older women and men in China. Based on data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2014 to 2018, a total of 1428 deceased older people were enrolled in the study, including 421 centenarians and 1007 non-centenarians.

Fertility experiences and later-life cognitive function among older adults in China.

Objectives: The relationship between fertility history and human health has long fascinated scholars; however, whether there is a link between number of children and cognitive function in older adults remains unclear. We investigated the associations between parity and the timing of first and last births with the cognitive function of older adults over 65.

Methods: The mini-mental state examination (MMSE) was selected as a tool to measure cognitive function.

Number of Births and Risk of Diabetes in China's Older Women.

As an important life event in individuals' life, childbirth will affect the health of women to different degrees. More and more attention has been paid to whether the number of births will affect the incident diabetes in elderly women, but there are few related studies. Based on the data of the Chinese Longitudinal Healthy Longevity Survey in 2018, 6,159 older women are selected as the study population.

Impact of fertility on the longevity of older rural Chinese women: an analysis of a longitudinal survey.

Background: This study evaluates the impact of fertility during the childbearing period on the longevity of older rural Chinese women and verifies whether any trade-off exists between women's longevity and their number of children to provide empirical evidence for improving health intervention policies and formulating active fertility policies in low-fertility countries.

Methods: Based on the data of the deaths of 1623 older adults aged 65 and above during 2014-2018 in the Chinese Longitudinal Healthy Longevity Survey, this study explores the relationship between the number of children born and older rural women's longevity using the ordinary least squares method. Furthermore, the impact of fertility on the longevity of men and women in rural and urban areas, along with other reproductive behaviours on older rural women's longevity, were analysed.

Volunteer Service and Well-Being of Older People in China.

Purpose: The social support theory suggested that involving older people in social activities could increase their level of social participation and interaction, which in turn improved their well-being. However, there has been a heated controversy about whether participating in volunteer services could enhance the well-being of older people, especially for the Chinese sample.

Method: Based on the data from the China Health and Retirement Longitudinal Study (CHARLS) in 2013, this paper used an ordered probit model to examine the impact of older people's participation in volunteer services on their well-being, as well as the differences in the impact across groups and the specific transmission mechanism.

Share Rose, Get Fun: The Influence of Donation on Happiness.

There is little literature on the impact of donation on individual wellbeing in China. This study examines individual donations in China to answer the question of whether helping others makes us happier and to provide policy implications for in Chinese context. Based on the 2012 Chinese General Social Survey (CGSS) data and using ordered logit and OLS as benchmark models, this study finds that donation can significantly increase individual happiness.

Internet Use and Depressive Symptoms Among Older Adults in China.

This study investigated the effect of using the Internet on depression symptoms of older Chinese, based on 7,801 adults aged over 60 years from the 2018 China Family Panel Studies. Results showed that the elderly who used the Internet reported lower depression scores, and the more frequent they use Internet, the lower their depression scores. Moreover, using the Internet for social contact and entertainment decreased the depression scores of the older adults, but when using Internet for learn, work, and commercial activity, the relief of depressive symptoms disappeared.

Does the Internet Use Improve the Mental Health of Chinese Older Adults?

The Internet has become an important part of daily life. However, older adults in China remain digital refugees amid the rapid development of digital information technology. This study attempts to scientifically answer how Internet use affects the subjective welfare of older adults.

Internet Use, Life Satisfaction, and Subjective Well-Being Among the Elderly: Evidence From 2017 China General Social Survey.

The research objectives of this study are to test the scientific propositions of whether Internet use promotes life satisfaction among the elderly, whether there is variability in the effect of Internet use on the well-being of the elderly, and through what channels Internet use affects the elderly's life satisfaction. Using data from the 2017 Chinese General Social Survey (CGSS), this paper employed linear regression, ordered logit model, and the propensity score matching (PSM) approach to investigate the association of Internet use with life satisfaction among the elderly in China. The results show that Internet use was significantly and negatively associated with the life satisfaction of the Chinese elderly.

N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm.

NF-κB is a major regulator of gene transcription involved in immune, inflammation, apoptosis and stress responses. However, the regulation of NF-κB is not completely understood. Here, we report that the N-Myc and STATs Interactor (NMI), an IFN-inducible protein, is an important negative regulator of NF-κB activity.

N-Myc-interacting protein (NMI) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-κB/p65.

The epithelial-mesenchymal transition (EMT) plays an essential role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and tumor progression. However, the mechanisms underlying this process are poorly understood. Many signaling pathways, including the NF-κB signaling pathway, trigger EMT during development and differentiation.

NMI mediates transcription-independent ARF regulation in response to cellular stresses.

The ARF tumor suppressor is a product of the INK4a/ARF locus, which is frequently mutated in human cancer. The expression of ARF is up-regulated in response to certain types of DNA damage, oncogene activation, and interferon stimuli. Through interaction with the p53 negative regulator MDM2, ARF controls a well-described p53/MDM2-dependent checkpoint.

[Insulin resistance and islet beta cell function in type 2 diabetes mellitus and non alcoholic fatty liver disease.].

Objective: To investigate insulin resistance and islet beta cell function in type 2 diabetes mellitus (T2DM) and non alcoholic fatty liver disease (NAFLD).

Methods: Two hundred and six study subjects were classified into 4 groups. Hepatic insulin resistance index (HIR), HOMA insulin resistance index (HOMA-IR) and Matsuda index (MSI) were used to assess insulin resistance.

[Study on the molluscicidal effect of META-Li against Oncomelania hupensis].

Objective: To evaluate the molluscicidal effect of the META-Li (40% META liquid formulation) against Oncomelania snails in laboratory and field.

Methods: The experiment of META-Li against the snails by spraying, immersion and climbing-inhibition test was carried out in laboratory. Spray method was performed in the field to compare with the wettable powder of 50% niclosamide ethanolamine salt.

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.

The protein-tyrosine phosphatase Shp2 plays an essential role in growth factor and integrin signaling, and Shp2 mutations cause developmental defects and/or malignancy. Previous work has placed Shp2 upstream of Ras. However, the mechanism of Shp2 action and its substrate(s) are poorly defined.

How are the regulators regulated? The search for mechanisms that impose specificity on induction of cell death and NF-kappaB activation by members of the TNF/NGF receptor family.

Signals emanating from receptors of the tumor necrosis factor/nerve growth factor (TNF/NGF) family control practically all aspects of immune defense and, as such, constitute potential targets for therapeutic intervention through rational drug design. Indeed, arrest of these signals by blocking ligand-receptor interactions enables effective suppression of a variety of activities that are implicated in various pathologies, such as T and B lymphocyte activation and growth, inflammation, fibroblast proliferation, and cell death. To be therapeutically useful, however, inhibition of signaling should be restricted by determinants of specificity, at least to the same degree observed when blocking activation of individual receptors.

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways.