Publications by authors named "Si-Qi Lyu"
Article Synopsis
- - This study explores how sex differences affect clinical outcomes in female and male patients with atrial fibrillation (AF) who have acute coronary syndrome (ACS) or stable coronary artery disease (SCAD) after undergoing coronary intervention.
- - Among 1,237 patients with AF and ACS, female patients were found to have a higher long-term risk of major adverse cardiovascular events (MACE) compared to males, with a hazard ratio of 1.45.
- - In contrast, female patients with AF and SCAD did not show a significant difference in long-term MACE risk compared to male patients, indicating that sex differences in prognosis may vary based on the type of coronary condition.
Article Synopsis
- A study was conducted on patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) to analyze the effects of rate and rhythm control strategies on health outcomes post-procedure.
- Results indicated that patients using rate control had significantly lower risks of major adverse cardiovascular and cerebrovascular events (MACCEs) and all-cause death compared to those not on rate control.
- The study suggests that while rhythm control improves overall mortality rates, rate control is more effective in reducing severe health complications related to AF and ACS or percutaneous coronary intervention (PCI).
Background: We aimed to explore the impact of adherence to Life's Simple 7 (LS7) metrics on risk of obstructive sleep apnea (OSA), and the impact of inflammation on the association, in adults in the United States.
Methods: Data from 13,825 community-dwelling adults aged ≥ 20 years recruited in the National Health and Nutrition Examination Surveys (NHANES) 2005-2008, 2015-2018 was analyzed. The LS7 score was calculated based on the AHA definition of LS7 metrics.
Background: The benefit-risk profile of direct oral anticoagulants (DOAC) therapy in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) has not been well established yet. This study aimed to evaluate the efficacy and safety of DOAC compared with vitamin K antagonists (VKA) in patients with HCM and AF.
Methods: PubMed, EMBASE, the Cochrane Library, and clinicaltrials.
Animal experiments have shown that high exposure to ethylene oxide (EO) can cause multiple system damages including the renal system. Recent studies have reported associations between exposure to EO and cancer, dyslipidemia, diabetes, and cardiovascular disease. However, the impact of exposure to EO on the prevalence and prognosis of chronic kidney disease (CKD) in humans is scarcely investigated.
View Article and Find Full Text PDFBackground: Early risk stratification with simple biomarkers is essential in patients with non-ST segment-elevation myocardial infarction (NSTEMI).
Objective: This study aimed to evaluate the association between plasma big endothelin-1 (ET-1) level and the SYNTAX score (SS) in patients with NSTEMI.
Methods: A total of 766 patients with NSTEMI undergoing coronary angiography were recruited.
Background And Aims: Stress-induced hyperglycemia (SIH) generally occurs in critical illness. Recently, glycemic gap (GAP) has been considered to be a superior indicator of SIH. However, data on the association between GAP and prognosis in ST-segment elevation myocardial infarction (STEMI) is limited.
View Article and Find Full Text PDFBackground: Early risk stratification of patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) has relevant implication for individualized management strategies. The -VASc and GRACE ACS risk model are well-established risk stratification systems. We aimed to assess their prognostic performance in AF patients with ACS or PCI.
View Article and Find Full Text PDFBackground: This study aimed to evaluate the association between plasma big ET-1 levels and long-term outcomes in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI).
Methods: A total of 930 patients were enrolled and followed up for a median duration of 2.3 years.
Article Synopsis
- The study evaluated the effectiveness of various bleeding risk scores (HAS-BLED, ORBIT, ATRIA, REACH, PARIS, PRECISE-DAPT) in patients with atrial fibrillation (AF) undergoing acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) while on anticoagulant and antiplatelet therapy.
- Out of 930 patients, BARC class ≥3 bleeding occurred in 36 patients (3.9%) and class ≥2 bleeding in 134 patients (14.4%), revealing that the HAS-BLED score had a poor predictive performance (c-statistic = 0.575) along with low-to-moderate performances from the other scores like ATRIA and ORBIT.
Background: This study aims to validate the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria in Chinese patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) who received both oral anticoagulants (OAC) and antiplatelet therapy (APT).
Methods: 930 consecutive patients with AF and ACS or undergoing PCI receiving both OAC and APT were recruited and followed up for 1 year. The primary endpoint was BARC type 3 or 5 bleeding.
Purposes: The POPular Risk Score (PRiS), a pharmacogenetic-driven algorithm consisting of CYP2C19 genotype, platelet reactivity, and clinical risk factors, is developed to evaluate ischemic risk and guide dual antiplatelet therapy (DAPT). This study aimed to evaluate the efficacy and safety of DAPT in accordance with the PRiS in patients undergoing drug-eluting stent (DES) implantation.
Methods: A total of 1757 patients recruited in this cohort study were divided into four groups according to the PRiS and type of P2Y12 receptor inhibitor treatment at discharge.
This study aimed to evaluate the predictive performance of the REACH, PARIS, BleeMACS, and PRECISE-DAPT scores in Chinese patients undergoing coronary drug-eluting stent (DES) implantation. A total of 1911 patients undergoing coronary DES implantation were consecutively recruited and followed up for 1 year. The primary endpoints were BARC type 3 or 5 bleeding and BARC type 2,3, or 5 bleeding.
View Article and Find Full Text PDFObjective: To evaluate the effect of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) therapy on the prognosis of patients with atrial fibrillation (AF).
Methods: A total of 1, 991 AF patients from the AF registry were divided into two groups according to whether they were treated with ACEI/ARB at recruitment. Baseline characteristics were carefully collected and analyzed.
Background And Aims: The aim of this study was to evaluate the association between body mass index (BMI) and mortality in atrial fibrillation (AF) patients with and without diabetes mellitus (DM).
Methods And Results: A total of 1991 AF patients were enrolled and divided into two groups according to whether they have DM at recruitment. Baseline information was collected and a mean follow-up of 1 year was carried out.
Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety of CYP2C19 genotype-guided antiplatelet therapy in patients with ACS or undergoing PCI. PubMed, EMBASE, the Cochrane Library and clinicaltrials.
View Article and Find Full Text PDFBackground: Elevated body mass index (BMI) is related with reduced mortality in various cardiovascular diseases.
Hypothesis: Gender-specific association between BMI and mortality exists in atrial fibrillation (AF).
Methods: In this multicenter observational study with a mean follow-up of 1 year, a total of 1991 AF patients were enrolled and divided into two groups based on the gender.