Publications by authors named "Si-Man Sun"
Mitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile.
Acta Pharmacol Sin
December 2021
Article Synopsis
- Mitochondria are vital for energy production and various cellular functions, particularly in mammalian oocytes, where they are crucial for germ cell development and avoiding inherited disorders.
- A systematic analysis of oocyte mitochondria was hindered by both the scarcity of oocyte samples and technical issues in studying mitochondrial proteins in live cells.
- This study utilized proximity labeling proteomics to identify 158 mitochondrial proteins in live mouse oocytes and demonstrated how exposure to the chemotherapy drug cisplatin caused changes in the levels of specific mitochondrial proteins.