Inhibitory effect of a natural phenolic compound, 3--coumaroyl-2-hydroxyquinic acid against the attachment phase of biofilm formation of through targeting sortase A.

The antibiofilm activity and molecular mechanism of a natural phenolic compound, 3--coumaroyl-2-hydroxyquinic acid (CHQA) against were investigated in this study. Crystal violet staining and XTT reduction assay demonstrated that CHQA could prominently prevent the biofilm formation of accompanied with decrease in metabolic activity of biofilm cells. Meanwhile, microscopic observations revealed that CHQA caused a huge collapse on the architecture of biofilm.