Multiple hysteroscopic surgery combined with fenestration for the treatment of diffuse uterine leiomyomatosis.

Objective: Diffuse uterine leiomyomatosis (DUL) is a unique growth pattern of fibroids that can lead to infertility. Due to numerous of myomas, a large amount of dilatant fluid as well as longer time are needed following traditional hysteroscopic myomectomy, and the absorption of irrigating fluids, combined with the pressure from uterine distension, can lead to fluid overload and/or dilutional hyponatremia, resulting in transurethral resection of the prostate (TURP) syndrome. In this study, we proposed a recommended technique for treating DUL to prevent above mentioned complications.

Accurate identification and surgical correction of type IIb uterine malformation using synchronized hysteroscopy and laparoscopy.

Objective: To introduce an effective approach for accurate identification and treatment of type IIb uterine malformation using synchronized hysteroscopy and laparoscopy.

Design: Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique. The patient provided written informed consent for video and data collection for research purposes.

An effective method using laparoscopy in treatment of upper vaginal leiomyoma.

Objective: To introduce an effective approach using laparoscopy in the treatment of upper vaginal leiomyoma.

Design: Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital of China Medical University.

Setting: Hospital.

Laparoscopic myomectomy using self-made retrieval bag to contain tissue extraction.

Objective: To introduce an effective approach using a self-made retrieval bag during laparoscopic myomectomy to contain tissue extraction.

Design: Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital of China Medical University.

Setting: University hospital.

Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer.

There is accumulating evidence that breast cancer 1 (BRCA1), sirtuin 1 (SIRT1), and epidermal growth factor receptor (EGFR) help to modulate cisplatin cytotoxicity. The role of dynamic crosstalk among BRCA1, SIRT1, and EGFR in cisplatin sensitivity remains largely unknown. We found that BRCA1, SIRT1, and EGFR levels were increased in cisplatin-resistant ovarian cancers compared with those in cisplatin-sensitive ovarian cancers.