[Application of PDCA circulation in reduction of the turnaround time of semen samples in the andrology laboratory].

Objective: To reduce the out-of-threshold (OOT) value of the turnaround time (TAT) of semen samples in the andrology laboratory and improve the clinical diagnosis and patients' satisfaction.

Methods: We retrospectively analyzed the defect rate of TAT of semen samples in the andrology laboratory in the first two quarters of 2018. In the second two quarters, we made a table of countermeasures targeting the causes of the defects using plan-do-check-act (PDCA) circulation and the fishbone diagram drawn with the brainstorm method, followed by supervision of the implementation of the measures and observation of the changes in the OOT value of TAT of semen samples.

A new mutation causes azoospermia and testicular meiotic arrest.

There are many unknown genetic factors that lead to infertility in nonobstructive azoospermia men. Here, we performed whole-exome sequencing in blood samples obtained from 40 azoospermia patients with meiotic arrest and found a novel c.151_154del (p.

[Pre-implantation genetic screening in intracytoplasmic sperm injection for infertile patients with high sperm DNA fragmentation index].

Objective: To investigate the application value of pre-implantation genetic screening (PGS) in intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) for infertile patients with high sperm DNA fragmentation index (DFI).

Methods: We selected 90 infertile patients undergoing ICSI-ET in our center from April 2015 to October 2016, 60 with sperm DFI =≥15% and 30 with sperm DFI <15%. Of the 60 cases with sperm DFI =≥15%, 30 received PGS-ICSI (high DFI-PGS group) while the other 30 did not receive PGS (high DFI-ICSI group).

Conjugated Microporous Polymers with Dense Sulfonic Acid Groups as Efficient Proton Conductors.

Proton-exchange membrane fuel cells, emerging as green and sustainable energy sources, have attracted extensive attention in recent decades. Porous organic polymers, which feature in high surface area values, tunable pore sizes, excellent thermal and chemical stabilities, and the flexibility to incorporate specific functional groups, have recently displayed their striking images as potential electrolytes for fuel cells. In this work, BO-CMP-1 and BO-CMP-2 that possess rich π-structure and permanent porosity and have high thermal and chemical stability were synthesized through Suzuki-Miyaura coupling reaction.

[Routine semen parameters and sperm morphological index of infertile males with partial globozoospermia].

Objective: To investigate the routine semen parameters and sperm morphological indexes of the patients with partial globozoospermia (PGZ).

Methods: We included in this study 100 infertile males with PGZ and another 180 non-PGZ infertile men as controls. According to the proportion of round-headed sperm (RHS) in the semen, we classified the PGZ males into five subgroups: 25%－40%, 41%－55%, 56%－70%, 71%－85%, and 86%－99% RHS.

Byproduct-catalyzed four-component reactions of aldehydes with hexamethyldisilazane, chloroformates, and nucleophiles in acetonitrile leading to protected primary amines, beta-amino esters, and beta-amino ketones.

Multicomponent reactions are a very powerful tool for the construction of complex organic molecules by using readily available starting materials. While most of the multicomponent reactions discovered so far consist of three components, the reactions with four or more components remain sparse. We have successfully developed several four-component reactions using a catalytic amount of water as a hydrolyzing agent to decompose byproduct chlorotrimethylsilane (TMSCl) to yield secondary byproduct HCl that serves as a catalyst.