The Novel HLA-C Allele, HLA-C*14:153, Identified in a Kidney Transplantation Recipient.

HLA-C*14:153 differs from HLA-C*14:02:01:01 by a non-synonymous nucleotide substitution in exon 2.

The HLA-C*14:152 Allele Was Identified Using a Next-Generation Sequencing Method.

HLA-C*14:152 differs from HLA-C*14:02:01:01 by a non-synonymous nucleotide substitution in exon 5.

The novel HLA-DQA1*03:75 allele identified in a Korean kidney donor.

HLA-DQA1*03:75 differs from HLA-DQA1*03:02:01:01 by a single non-synonymous nucleotide substitution in exon 2.

Unique ethnic features of mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia.

DDX41 mutations are associated with hematologic malignancies including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but the incidence in idiopathic cytopenia of undetermined significance (ICUS) is unknown. We investigated the incidence, genetic characteristics, and clinical features of DDX41 mutations in Korean patients with ICUS, MDS, or AML. We performed targeted deep sequencing of 61 genes including DDX41 in 457 patients with ICUS (n=75), MDS (n=210), or AML (n=172).

Delayed intra-articular inflammatory reaction due to poly-L-lactide bioabsorbable interference screw used in anterior cruciate ligament reconstruction.

Bioabsorbable interference screws have replaced metal interference screws in anterior cruciate ligament reconstruction surgery because they have several advantages. Poly-L-lactide (PLLA) is one of the commonly used materials for bioabsorbable interference screws. PLLA produces a lower inflammatory reaction than polyglycolide as a result of its slower degradation rate and better biocompatibility.