Publications by authors named "Si-Hao Jin"
Article Synopsis
- - The study investigates the connection between the Nrf2/PHB2 pathway and sepsis-associated acute lung injury (SA-ALI), highlighting reduced Nrf2 levels in patients and its impact on inflammation and mitochondrial function.
- - A mouse model and cell-based experiments demonstrated that downregulation of Nrf2 worsened ALI, while Nrf2 overexpression improved mitochondrial health and reduced oxidative stress.
- - The research concludes that Nrf2 is crucial for alleviating SA-ALI by directly influencing PHB2 transcription, thereby maintaining mitochondrial function in lung cells.
Dehydrocostus lactone (DHL), a natural sesquiterpene lactone isolated from the traditional Chinese herbs and L., has important anti-inflammatory properties used for treating colitis, fibrosis, and Gram-negative bacteria-induced acute lung injury (ALI). However, the effects of DHL on Gram-positive bacteria-induced macrophage activation and ALI remains unclear.
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