[Electroacupuncture of "Gongsun" (SP4) alleviates oxidative stress injury and promotes normal follicle development by regulating keap1/Nrf2/HO-1 signaling in rats with premature ovarian insufficiency].

Objectives: Based on the theory of "Gongsun (SP4) connects the Thoroughfare Vessel" of the "eight confluence acupoints", the effect of electroacupuncture (EA) at SP4 on Kelch-like epichlorohydrin associated protein factor 1 (Keap1)/ nuclear factor-erythroid 2 related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) signaling pathway was observed in rats with premature ovarian insufficiency (POI) for exploring its underlying mechanisms in treating POI.

Methods: Thirty-two female SD rats were randomly divided into 4 groups:blank, model, EA and medication, with 8 rats in each group. The POI model was established by intraperitoneal injection of cyclophosphamide.