Publications by authors named "Si-Cong Huang"
Background: Xianglian pill (XLP) is a traditional Chinese medicine (TCM) that is widely used to treat ulcerative colitis (UC). However, its mechanism of action in UC is unclear.
Purpose: This study aimed to investigate the mechanism of action of XLP in treating UC and role of M1 macrophage polarization in this process.
Article Synopsis
- The study identified high levels of MCF2L in hepatocellular carcinoma (HCC) tissues, suggesting it plays a role in resistance to sorafenib, a common cancer treatment.
- Various experiments confirmed that reducing MCF2L levels increased cell death when treated with sorafenib, and that this process is linked to ferroptosis, a specific type of cell death.
- The research also indicated that MCF2L influences the PI3K/AKT signaling pathway via a RhoA/Rac1-dependent mechanism, making it a potential target for overcoming treatment resistance in HCC.
Background: High tibial osteotomy (HTO) is an effective surgical technique that can stop or inhibit the progression of unicompartmental knee osteoarthritis (KOA) to avoid or postpone the need for knee arthroplasty in patients. Whether opening-wedge high tibial osteotomy (OWHTO) is superior to closing-wedge high tibial osteotomy (CWHTO) in treating unicompartmental KOA remains controversial.
Methods: Databases (Cochrane Library, EMBASE, and PubMed) were searched from their establishment to July 1, 2018 for randomized controlled trials comparing the application of OWHTO to CWHTO in patients with unicompartmental KOA.