Publications by authors named "Si-Chu Liu"
[Analysis of Therapeutic Efficacy and Adverse Prognostic Factors of Secondary Central Nervous System Lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2024
Article Synopsis
- The study investigates the effectiveness and prognostic factors of induction therapy for secondary central nervous system lymphoma (SCNSL) using patient data from a hospital between 2010 and 2021.
- It involves 37 patients with diffuse large B-cell lymphoma and finds a 2-year overall survival rate of 46.01% with varying outcomes based on treatment type.
- The analysis indicates that age, sex, and disease stage are significant prognostic factors, suggesting that a combination of HD-MTX and TMZ could enhance patient outcomes while emphasizing the usefulness of gene sequencing for prognosis evaluation.
Background: High-dose methotrexate (HD-MTX) combined with other chemotherapeutic agents is an effective treatment for patients with newly diagnosed primary central nervous system lymphoma (PCNSL); however, some patients have adverse reactions.
Aim: To retrospectively evaluate disease outcomes and mutational profiles in newly diagnosed PCNSL patients treated with a zanubrutinib/HD-MTX combination regimen.
Methods: Nineteen newly diagnosed PCNSL patients were treated with zanubrutinib/HD-MTX until disease progression, intolerable toxicities, or physician/patient-directed withdrawal.
Background: The incidence of primary cardiac lymphoma (PCL) is increasing, but the optimal management approach remains unclear. We assessed the clinical characteristics of a single-centre cohort with the goal of determining the optimal management approach. The treatment outcomes and prognostic factors are reported.
View Article and Find Full Text PDFObjective: To investigate the clinical efficacy of high dose methotrexate (HD-MTX), temozolomide (TMZ), and rituximab (R) in the treatment of patients with primary central nervous system lymphoma (PCNSL).
Methods: Clinical data of patients with PCNSL diagnosed and treated in Guangdong Provincial People's Hospital from February 2010 to May 2017 were collected. First, patients were given 6-8 cycles of MTX (3.
[Effects of Down-regulating PPP2R5C Expression on Expression Profile of TAL1-related Regulating Genes in Jurkat Cells].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2015
Objective: Based on our previous study showing the inhibition of lenkemia T cell proliferation by down-regulating PPP2R5C expression, this study was aimed to analyze the influence of down-regulating PPP2R5 expression via RNA interference on genes relatied with TAL1 signaling pathway by using gene chip technique.
Methods: The PPP2R5C-siRNA799 was transduced into Jurkat cells by nucleofection, the total RNA was isolated from treated Jurkat cells after culture for 48 hours; the target sequences were prepared by revevse transcription after mRNA purification, and were hybridized with affymetrix gene expression profile chip 3' IVT. The original image data were collected using affymetrix gene chip scanner 3 000, and the gene expression profile was analyzed using gene spring GX 11.
[Change of T cell TCR-CD3 complex-mediated gene expression pattern in lead poisoning patients].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
March 2013
Article Synopsis
- The study aimed to investigate how gene expression of the T cell TCR-CD3 complex is affected in patients with lead poisoning.
- Real-time PCR found that, compared to a control group, lead poisoning patients showed higher expression levels of CD3γ and CD3ε, but lower levels of CD3δ, indicating altered immune responses.
- The findings suggest that changes in CD3 gene expression could indicate immune system issues in lead poisoning patients, with CD3ε potentially serving as a useful screening marker for immune function.
[Change in the pattern of peripheral blood TCR V β gene repertoire in occupational lead-exposed workers].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2011
Aim: To investigate the distribution and clonality of TCR Vβ subfamily in peripheral blood from workers exposed to lead, in order to understand the change in T cell immunity of occupational lead-exposed workers.
Methods: The CDR3 of TCR Vβ 24 subfamily genes was amplified in peripheral blood mononuclear cells (PBMC) from 6 lead-exposed workers and 6 healthy individuals using RT-PCR, the positive PCR products were further subjected by genescan analysis to identify T cell clonality.
Results: All 24 TCR Vβ subfamilies were detected in PBMC from 6 healthy individuals which all have polyclonal patterns.