Synopsis of recent research by authors named "Si-Chi Xu"
- Si-Chi Xu's research primarily focuses on the molecular mechanisms underlying cardiac dysfunction and hypertrophy, exploring the roles of specific proteins such as S100a8/9 and USP28 in these processes, especially within the context of diabetes and aging.
- Recent findings indicate that S100a8/9 plays a significant role in promoting cardiac hypertrophy through the upregulation of FGF23 in mouse models, while USP28 has been identified as a key suppressor of mitochondrial dysfunction and related cardiac issues in diabetic hearts.
- Xu's work also delves into the implications of COVID-19 on cardiac health, revealing insights into the mechanisms of cardiac injury associated with the virus, alongside studies on age-related cardiac changes and potential therapeutic targets like FNDC5 and osteocrin in mitigating cardiovascular diseases.
