Publications by authors named "Si-Chen Song"
Article Synopsis
- Researchers isolated 15 new prenylated coumarins (called asiaticasics A-O) from the ethyl acetate fraction of Toddalia asiatica, along with 9 known derivatives.
- The structures of these new compounds were confirmed using spectroscopic analysis and reference data.
- Biological tests showed compounds 3 and 12 exhibited anti-inflammatory effects, with compound 12 reducing pyroptosis in J774A.1 cells by inhibiting the NLRP3 inflammasome, supported by both biochemical and morphological evidence.
Ten undescribed diterpenoids namely rubellawus E-N of structural types pimarane (1, 3-4), nor-abietane (2), nor-pimarane (5-6), isopimarane (7-9), and nor-isopimarane (10), along with eleven known compounds, were isolated and identified from the aerial parts of Callicarpa rubella Lindl. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analyses and quantum chemical computations. Pharmacologically, almost all the compounds exhibited a potential inhibitory effect on oxidized low-density lipoprotein-induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment of atherosclerosis.
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- Three new compounds called Callicarpnoids A-C were discovered from the stems of Callicarpa arborea, and their structures were determined using advanced techniques like spectroscopic analysis and X-ray diffraction.
- Compounds 2 and 3 showed strong anti-cancer activity against breast and colorectal cancer cells, with effective concentrations ranging from 5.2 to 7.2 μM that were comparable to existing treatments.
- Analysis of protein levels indicated that these compounds promote cancer cell death (apoptosis) by increasing certain proteins (like Bax) and decreasing others (like caspases), suggesting they work through multiple pathways to induce apoptosis.