Rewiring the pneumococcal capsule pathway for investigating glycosyltransferase specificity and genetic glycoengineering.

Virtually all living cells are covered with glycans. Their structures are primarily controlled by the specificities of glycosyltransferases (GTs). GTs typically adopt one of the three folds, namely, GT-A, GT-B, and GT-C.

Acquisition of regulator on virulence plasmid of hypervirulent allows bacterial lifestyle switch in response to iron.

Hypervirulent causes liver abscess and potentially devastating metastatic complications. The majority of -induced liver abscess are caused by the CG23-I sublineage of hypervirulent . This and some other lineages possess a >200-kb virulence plasmid.