Bacterial neuraminidase inhibitory chalcones from flowers of Coreopsis lanceolata, their kinetic characterization and antibiofilm effect.

Background: Bacteria within biofilms are thousand times more resistant to antibiotics. Neuraminidase is a crucial enzyme for bacterial adhesion and biofilm formation, it hydrolyzes glycosidic residue of glycoproteins, glycolipids, and oligosaccharides. Coreopsis lanceolata L.

New Class of Tyrosinase Inhibitors, Rotenoids, from .

A series of rotenoids including a new one from the seeds of were found to have significant potential as tyrosinase inhibitors. All of the isolated rotenoids () displayed inhibitory activity against tyrosinase, both as a monophenolase for the oxidation of l-tyrosine and as a diphenolase for the oxidation of l-DOPA. The three most active compounds (, , and ) showed significant monophenolase inhibition with IC values of 2.