Biocompatibility of light responsive materials prepared for accommodative intraocular lenses manufacturing.

Aim: To investigate the biocompatibility and bacterial adhesion properties of light responsive materials (LRM) and analyze the feasibility and biosafety of employing LRM in the preparation of accommodative intraocular lenses (AIOLs).

Methods: Employing fundamental experimental research techniques, LRM with human lens epithelial cells (hLECs) and human retinal pigment epithelium cells (ARPE-19 cells) were co-cultured. Commercially available intraocular lenses (IOLs) were used as controls to perform cell counting kit-8 (CCK-8), cell staining under varying light intensities, cell adhesion and bacterial adhesion experiments.

Randomized controlled trial on the efficacy and safety of autologous serum eye drops in dry eye syndrome.

Background: Autologous serum eye drops (ASEDs), a novel treatment derived from blood serum, have emerged as a groundbreaking solution for managing dry eye syndrome (DES). These drops have shown significant promise in relieving the distressing symptoms of DES. This study aimed to evaluate the safety and effectiveness of ASEDs compared to traditional treatments, which often prove inadequate or result in unwanted side effects, particularly in individuals with moderate-to-severe DES.

Spaceflight-associated neuro-ocular syndrome: a review of potential pathogenesis and intervention.

With the continuing progress in space exploration, a new and perplexing condition related to spaceflight ocular syndrome has emerged in the past four decades. National Aeronautics and Space Administration (NASA) has named this condition "spaceflight-associated neuro-ocular syndrome" (SANS). This article gives an overview of the current research about SANS and traditional Chinese medicine (TCM) by analyzing the existing publications on PubMed and CNKI and reports from NASA about SANS, summarizing the potential pathogenesis of SANS and physical interventions for treating SANS, and discussing the feasibility of treating SANS with TCM.

[Analysis of the Related Risk Factors of Cerebral AVM Hemorrhage and the Relationship Between EPCs and SDF-1 in Brain AVM].

Objective: To explore the related risk factors of hemorrhage in human brain cerebral arteriovenous malformations (AVM) and the relationship between endothelial progenitor cells (EPCs) content and stromal cell-derived factor-1 (SDF-1) in different ages.

Methods: A retrospective analysis was conducted on 130 patients with cerebral AVM who underwent surgical treatment from May 2012 to October 2018. Univariate and multivariate logistic analysis was used to investigate the related risk factors of cerebral AVM hemorrhage.

Recurrent mutation in a Chinese family with congenital aniridia, progressive cataracts and mental retardation.

Background: One prominent pathological feature of congenital aniridia is hypoplasia of the iris, often accompanied by other eye abnormalities. The objective of this study is to identify gene mutations responsible for autosomal dominance in a Chinese family with congenital aniridia, progressive cataracts and mental retardation.

Methods: A total of 11 family members, including 6 affected and 5 unaffected individuals were recruited.

Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment.

Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments.

Mutation analysis in Chinese families with autosomal dominant hereditary cataracts.

Purpose: To identify the molecular basis and clinical phenotype in three Chinese families with hereditary cataracts.

Methods: Detailed family history and clinical data were recorded. The phenotypes were documented using slit-lamp photography.

A novel p.G112E mutation in BFSP2 associated with autosomal dominant pulverulent cataract with sutural opacities.

Purpose: To identify the genetic defect in a Chinese family with bilateral pulverulent sutural cataract.

Materials And Methods: A three-generation family with congenital cataract was recruited in the study. The study protocol followed the principles of the Declaration of Helsinki.

[Detection of differentially expressed lumican gene mRNA level in scleral tissue in human eye].

Objective: To identify differentially expressed lumican in scleral tissue of eyes with primary open-angle glaucoma (POAG) and high myopia (HM).

Methods: Total RNA was isolated from scleral tissue of cadaveric eyes derived from normal donors, patient's eyes with diagnosed glaucoma and high myopia who accepted trabeculectomy. RNA was amplified, RT-PCR was used to measure the levels of mRNA.

A novel p.F206I mutation in Cx46 associated with autosomal dominant congenital cataract.

Purpose: To identify the genetic defect in a Chinese family with bilateral congenital cataract.

Methods: A three-generation family was recruited in this study. Detailed family history and clinical data were recorded.

Identification of the p. R116H mutation in a Chinese family with novel variable cataract phenotype: evidence for a mutational hot spot in αA-crystallin gene.

Purpose: To report the recurrent p.R116H mutation in the αA-crystallin gene (CRYAA) which causes a novel variable cataract phenotype, and to determine whether this mutation represents a mutational hot spot.

Methods: Family history and clinical data were recorded.

A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer.

Congenital cataract-microcornea syndrome (CCMC) is a clinically and genetically heterogeneous condition characterized by lens opacities and microcornea. It appears as a distinct phenotype of heritable congenital cataract. Here we report a large Chinese family with autosomal dominant congenital cataract and microcornea.

Rigid iris-fixated phakic lens implantation for high myopia: novel trapezoidal corneal versus scleral incisions.

Purpose: To compare refractive performance of implantation of an iris-fixated phakic intraocular lens (PIOL) through a novel trapezoidal corneal and a scleral tunnel incision.

Methods: Sixty-nine eyes selected to undergo PIOL implantation were randomly assigned to 1 of 2 groups: 5.2-mm trapezoidal corneal incision (TCI), 34 eyes; 5.

The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia.

Purpose: High myopia is a severe hereditary ocular disease leading to blindness. LAMA1 (alpha subunit of laminin) is a promising candidate gene for high myopia present in the MYP2 (myopia 2) region. The purpose of this study was to determine if high myopia is associated with single nucleotide polymorphism (SNP) variants in LAMA1 in Chinese subjects.

Novel beta-crystallin gene mutations in Chinese families with nuclear cataracts.

Objective: To investigate the molecular genetic background in families with nuclear congenital cataract.

Methods: Family history and clinical data were recorded. Ten candidate genes were screened for causative mutations.

A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family.

Purpose: To identify the underlying genetic defect in a Chinese family affected with autosomal dominant congenital nuclear cataract.

Methods: A four-generation Chinese family with inherited nuclear cataract phenotype was recruited. Detailed family history and clinical data were recorded.

[Evaluation of intraocular lens power after keratorefractive surgery by IOLMaster].

Objective: To study the accuracy of different formulas predicting intraocular lens (IOL) power after excimer laser keratorefractive surgery in order to calculate the diopter of IOL accurately in the clinical practice.

Methods: One hundred and eleven cases (222 eyes) were collected in this study and were divided into two groups (A and B) according to their axial length. Fifty-nine cases (118 eyes) with axial lengths of 24-26 mm were taken as group A, and 52 cases (104 eyes) with axial length of more than 26 mm were taken as group B.

Autosomal dominant congenital nuclear cataracts caused by a CRYAA gene mutation.

Purpose: We sought to identify the genetic defect in a four-generation Chinese family with autosomal dominant congenital nuclear cataracts, examine the clinical features in detail and demonstrate the functional analysis of a candidate gene in the family.

Methods: Family history data were recorded. Clinical and ophthalmological examinations were performed on affected and unaffected family members.

[Progress in pathogenic genes and their functions of congenital cataract].

Congenital cataract is the common cause of visual disability in children. Inherited isolated (non-syndromic) cataract represents one third of cases. Currently, at least 22 specific genes associated with isolated inherited cataract have been identified: ten crystallin genes: CRYAA, CRYAB, CRYBA1/A3, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGC, CRYGD, CRYGS; 4 membrane protein genes: GJA3, GJA8, MIP, LIM2; three growth and transcription factor genes: PITX3, MAF, HSF4; two cytoskeletal protein gene: BSFP1, BSFP2; chromatin modifying protein-4B gene: CHMP4B, EPHA2 and NHS, it is likely that more genes remain to be discovered.

[Quality of vision in patients with aspherical diffractive multifocal intraocular lens implantation].

Objective: To evaluate the visual performance of patients with Tecnis ZM900 aspherical diffractive multifocal intraocular lens (MIOL) as compared with aspherical monofocal intraocular lens (IOL).

Methods: A prospective nonrandomized controlled study was conducted. Consecutively 114 senile cataract patients (114 eyes) received phacoemulsification and IOL implantation, 57 patients (57 eyes) were implanted Tecnis ZM900 MIOL (multifocal group) and 57 patients (57 eyes) were implanted aspherical Tecnis ZA9003 IOL (monofocal group).

Spontaneous dislocation of a Verisyse phakic intraocular lens with severe corneal endothelial cell loss.

Purpose: To report a case of spontaneous dislocation of a Verisyse phakic intraocular lens (PIOL) with severe corneal endothelial cell loss.

Methods: A 29-year-old woman with no history of trauma presented with complaint of blurred vision in the right eye of 5 months' duration. History included uneventful implantation of a PIOL bilaterally to correct high myopia in January 2007.

[Cortical plasticity in blind individual].

The cognitive mechanisms and functional brain imaging research on blind individuals provide special information for exploring the plasticity of the developing human brain. This paper focuses on five aspects of recent progress in this field: (1) the behavior compensation of the blind; (2) the influence of early visual deprivation and later visual deprivation on cross-modal reorganization; (3) the relationship between the complexity of task requirement and cross-modal reorganization; (4) the relationship between the sensitive periods of the visual system and the time course of cross-modal reorganization; (5) the neural mechanisms of cross-modal reorganization. These findings contribute greatly to the theoretical basis of the rehabilitation of individuals with perceptual deficits.