Nanotherapy targeting anti-aging skin cells: harnessing ursolic acid from Linn for precision skin rejuvenation - a molecular perspective.

The necessity of this work lies in the innovative application of nanotherapy to target anti-ageing skin cells, utilising ursolic acid from Linn for precise and effective skin rejuvenation at a molecular level. Ursolic acid (UA), a pentacyclic triterpenoid compound, found in abundance in the plant Linn, has long been recognised for its potential anti-inflammatory, antioxidant, and anti-ageing properties. Despite its promising benefits, the direct application of UA in skincare has been limited, primarily due to its low aqueous solubility and poor skin penetration.