Ensemble stacking of machine learning models for air quality prediction for Hyderabad city in India.

Hyderabad, one of the rapidly developing cities in India, is facing with severe air pollution due to rapid urbanization, industrial operations, and climatic factors. To alleviate the negative impact on human health and the environment, accurate monitoring and forecasting of air quality are essential. This research utilized various machine learning models, such as XGBoost, LarsCV, Bayesian Ridge, AdaBoost, and ensemble stacking methods, to forecast the air quality index (AQI) using data from August 2016 to October 2023, which included 18 different air pollutants, including meteorological parameters.

Impact of Asana and Pranayama on Heart Rate Variability and Cardiac Autonomic Functions in Young Femaleswith Premenstrual Syndrome: An Interventional Clinical Trial.

Background: Premenstrual syndrome (PMS) is known to be a prevalent health concern affecting a significant number of women globally and yoga is found to be beneficial in such psychosocial disorders.

Objective: To evaluate the effectiveness of a structured yoga intervention by comparing pre-and post-intervention changes in the severity of PMS symptoms and cardiac autonomic functions in young, healthy female students over the course of three menstrual cycles.

Methods: The present study is a trial conducted in the Department of Physiology, Kasturba Medical College, Manipal which consists of 49 young, healthy female volunteers suffering from moderate PMS.

Causes and risk factors for stillbirth in India: A systematic review protocol.

Objectives: Stillbirths, the tragic loss of a baby before or during delivery, presents a profound global health concern. Investigating the diverse causes and risk factors is essential to develop targeted interventions, enhance perinatal care, and reduce the incidence of this devastating outcome. The aim of this study was to identify the causes and possible risk factors of stillbirths in India.

Experimental investigation on the effect of nano-silica on reinforced concrete Beam-column connection subjected to Cyclic Loading.

Beam-column joints are crucial load transmission zones because they face concentrated forces from both the beams and the columns. High shear and axial stresses caused by these concentrated forces in the area of the joint may result in decreased joint strength. This article proposes a new beam-to-column connection developed for precast concrete-resisting frames.

Artificial intelligence and visual inspection in cervical cancer screening.

Introduction: Visual inspection with acetic acid is limited by subjectivity and a lack of skilled human resource. A decision support system based on artificial intelligence could address these limitations. We conducted a diagnostic study to assess the diagnostic performance using visual inspection with acetic acid under magnification of healthcare workers, experts, and an artificial intelligence algorithm.

Exploring combined herbal extract-loaded phytoniosomes for antimalarial and antibacterial activity against methicillin-resistant .

Antibiotic resistance in the context of treating malarial infections is a major challenge in India. Home remedies such as thulasi leaves (), black pepper seeds (, clove buds (), cinnamon bark (), and nilavembu whole plant powder () were taken to explore antimalarial and methicillin-resistant (MRSA) activity. Among the five extracts, the best two extracts, and extract, showed the presence of Quercetin.

Judicious use of antisnake venom in the present period of scarcity.

Context: Although antisnake venom (ASV) has been used for many years, selection of an optimal dose is a debated issue due to acute shortage of ASV in India. Despite evidence for smaller doses, most centers still use conventional doses.

Aims: This study aimed to evaluate the effects of two different dosage regimens on the outcome of patients with snake envenomation, using a retrospective descriptive analysis of patient records admitted in our hospital.

Bilateral arterial variation in the upper extremity--an anatomical case report.

We report a case of bilateral arterial variation in the upper extremities of a male cadaver. In the left upper extremity, it was observed that the ulnar artery was arising from axillary artery. This ulnar artery was superficial throughout its course at the medial aspect of the arm and forearm.

Early second trimester uterine scar rupture.

Spontaneous uterine scar rupture can be lethal in pregnant women. A spontaneous uterine scar rupture in the early mid-trimester is rare and difficult to diagnose. This is a case of a 30-year-old woman (G2P1L1) at 19 weeks of gestation and having undergone a previous caesarean section presented with acute abdomen in shock.

Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice.

Introduction: Expression of the A and B forms of progesterone receptor (PR) in an appropriate ratio is critical for mammary development. Mammary glands of PR-A transgenic mice, carrying an additional A form of PR as a transgene, exhibit morphological features associated with the development of mammary tumors. Our objective was to determine the roles of estrogen (E) and progesterone (P) in the genesis of mammary hyperplasias/preneoplasias in PR-A transgenics.

Overexpression of progesterone receptor A isoform in mice leads to endometrial hyperproliferation, hyperplasia and atypia.

A delicate balance in estrogen and progesterone signaling through their cognate receptors is characteristic for the physiologic state of the endometrium, and a shift in receptor isotype expression can be frequently found in human endometrial pathology. In this study, using a transgenic mouse model, we examined the mechanisms whereby alterations in progesterone receptor (PR) isotype expression leads to endometrial pathology. For an experimental model, we used transgenic mice (PR-A transgenics) carrying an imbalance in the native ratio of the two PR isoforms A and B (PR-A and PR-B) through the expression of additional A form and examined their uterine phenotype under different hormonal regimens, using various criteria.

Relative efficiency of polymerase chain reaction and enzyme-linked immunosorbant assay in determination of viral etiology in congenital cataract in infants.

Background: Perinatal viral infections of fetus are among the leading causes of congenital cataract and identifying the viral etiology is important.

Objectives: To detect the presence of Rubella virus (RV), herpes simplex virus (HSV) and cytomegalovirus (CMV) in lens aspirate specimens obtained from patients with congenital cataract and relate the results with serology.

Setting And Design: Prospective study carried out in tertiary care hospital.

Toxoplasma gondii detection by nested polymerase chain reaction in lens aspirate and peripheral blood leukocyte in congenital cataract patients: the first report from a tertiary eye hospital in India.

Purpose: To detect T. gondii DNA and specific antibodies in lens aspirates (LA) and peripheral blood leucocytes (PBL) of congenital cataract patients.

Methods: ELISA for T.

Relative susceptibility of six continuous cell lines for cultivation of Chlamydia trachomatis strains.

Since susceptibility of a cell line is an important factor for cultivation of Chlamydia trachomatis, McCoy, HeLa, BHK-21, HEp-2, Vero and A549 cell lines were tested for this characteristic. These were inoculated with 150 infection-forming units (IFU) of C. trachomatis A, B, Ba and C serovars.

Optimization of a polymerase chain reaction (PCR) for increasing its sensitivity to detect Chlamydia pneumoniae specific genome.

Being an intracellular parasite, Chlamydia pneumoniae disseminates to organs outside the respiratory tract and causes chronic diseases in human. Nucleic acid-based method such as polymerase chain reaction (PCR) as diagnostic test has greater sensitivity and specificity than conventional microbiological techniques. The PCR protocol consisting of touchdown technique to detect C.

Nested reverse transcription polymerase chain reaction for the detection of rubella virus in clinical specimens.

Background & Objective: Rubella virus (RV) is one of the leading causes of childhood blindness in India. In this study we applied an optimized nested reverse transcription polymerase chain reaction (nRT-PCR) to detect RV in clinical specimens.

Methods: nRT-PCR was optimized using total RNA extracted from standard strain of RV using nested sets of primers specific for E1 open reading frame.

Effect of c-neu/ ErbB2 expression levels on estrogen receptor alpha-dependent proliferation in mammary epithelial cells: implications for breast cancer biology.

Mammary development and tumorigenesis are profoundly influenced by signaling pathways under the control of c-erbB2/c-neu and estrogen receptor alpha (ERalpha). Signaling through ERalpha is essential for ductal growth during puberty. In mice overexpressing wild-type c-neu in mammary epithelial cells, Tg (c-neu), ductal growth is impaired.

Polymerase chain reaction to detect Chlamydia trachomatis and adenovirus in the nasopharyngeal aspirates from paediatric patients with lower respiratory infections.

Polymerase chain reaction (PCR) was evaluated to detect Adenoviruses and Chlamydia trachomatis on nasopharyngeal aspirates (NPA) obtained 4-5 days after the onset of lower respiratory tract illness in children. Forty-five nasopharyngeal aspirates (NPA) from 45 children with lower respiratory tract infections were processed for the detection of C. trachomatis and Adenovirus by Fluorescent antibody test (FAT), culture and PCR for the cryptic plasmid of C.

Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice.

Transforming growth factor (TGF)-beta1 is a potent inhibitor of mammary epithelial proliferation. In human breast, estrogen receptor (ER)-alpha cells rarely co-localize with markers of proliferation, but their increased frequency correlates with breast cancer risk. To determine whether TGF-beta1 is necessary for the quiescence of ER-alpha-positive populations, we examined mouse mammary epithelial glands at estrus.

Persistent mammary hyperplasia in FVB/N mice.

The inbred FVB/N mouse strain is widely used for creating transgenic mice. Over the past decade, persistent mammary hyperplasia has been detected in many multiparous FVB/N female mice sent to the University of California, Davis (UCD) Mutant Mouse Pathology Laboratory (MMPL) by a number of different laboratories. However, the experimental details concerning most specimens were not always available.

Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling.

The FVB/N mouse strain is widely used in the generation of transgenic mouse models. We have observed that mammary glands of wild-type virgin female FVB/NCr mice frequently have the morphologic and histologic appearance of a gland during pregnancy. By 13 months of age, the mammary glands of more than 40% of the mice examined had lobuloalveolar hyperplasia that was characterized by the presence of secretory alveoli and distended ducts apparently containing secretory material.