Publications by authors named "Shyamal Subramanyan"
Article Synopsis
- Pathogenic mutations in the BRCA1 and BRCA2 genes are linked to several types of hereditary cancer, but inactivating both copies (bBRCA1/2) can be lethal in embryos and reduce cell growth.
- Researchers identified specific genetic changes commonly found in bBRCA1/2 tumors that could boost cell proliferation and studied them through various analytical methods, including examining mutation patterns in databases.
- In their results, they discovered that bBRCA1/2 tumors often showed large genomic deletions, identified genes that influenced cell growth, and validated some candidate genes (like RIC8A) as crucial for tumor viability despite the loss of BRCA1 and BRCA2.
