Osmaborane Clusters with B and B Rings Stabilized in the Coordination Sphere of {OsL} (L = η-CMe or H(PPh)).

New synthetic routes have been developed to synthesize osmaborane clusters featuring B and B rings in the coordination spheres of osmium. Thermolysis of [Os(PPh)Cl], in the presence of excess of [BH·THF] led to the formation of [Os(PPh)H(η-BH)], along with [HOs(PPh)BH], . Cluster features a planar tetraborane ring coordinated to an osmium center in an η fashion.

Quantifying variation in cooperative B-H bond activations using Os(ii) and Os(iii) κ-,-chelated complexes: same, but different.

In an effort to investigate small molecule activation by heavier transition metal (TM) based κ-,-chelated species, we have synthesised a series of bis-κ-1,3-,-chelated complexes of osmium, [Os(PPh)(κ-,-L/L)], 2a-b, and [Os(PPh)(L/L)(κ-,-L/L)], 3a-b (2a and 3a: L[double bond, length as m-dash] = CHNS; 2b and 3b: L = CHNS), from the thermolysis of [Os(PPh)Cl], 1, with a potassium salt of heterocyclic ligands L and L. The former complexes are diamagnetic in nature, while the EPR spectra, XPS study and density functional theory (DFT) calculations have substantiated the paramagnetic behaviour of 3a-b with a significant spin contribution from non-innocent ligands. These species were engaged in B-H activation of boranes utilizing the combined effect of hemilability and metal-ligand cooperativity (MLC), where 2a-b upon treatment with BH·SMe yielded Os(σ-borate)hydride complexes, [Os(PPh)(H){κ-,,'-BH(L/L)}], 4a-b (4a: L = CHNS; 4b: L = CHNS).

A cheminformatics and network pharmacology approach to elucidate the mechanism of action of γ-carbonic anhydrase inhibitors.

Background: (Mtb) carbonic anhydrases (CAs) are critical enzymes that regulate pH by converting CO to HCO , essential for Mtb's survival in acidic environments. Inhibiting γ-CAs presents a potential target for novel antituberculosis drugs with unique mechanisms of action.

Objective: This study aimed to explore the biological connections underlying Mtb pathogenesis and investigate the mechanistic actions of antituberculosis compounds targeting the Cas9 protein.

Physiological modeling of the metaverse of the Mycobacterium tuberculosis β-CA inhibition mechanism.

Tuberculosis (TB) is an infectious disease that primarily affects the lungs of humans and accounts for Mycobacterium tuberculosis (Mtb) bacteria as the etiologic agent. In this study, we introduce a computational framework designed to identify the important chemical features crucial for the effective inhibition of Mtb β-CAs. Through applying a mechanistic model, we elucidated the essential features pivotal for robust inhibition.

Surface Engineered Osteoblast-Extracellular Vesicles Serve as an Efficient Carrier for Drug and Small RNA to Actively Target Osteosarcoma.

Osteosarcoma (OS) is a rare malignant tumor that affects soft tissue and has high rates of lung metastasis and mortality. The primary treatments for OS include preoperative chemotherapy, surgical resection of the lesion, and postoperative chemotherapy. However, OS chemotherapy presents critical challenges related to treatment toxicity and multiple drug resistance.

Synergistic Interaction between Polysaccharide-Based Extracellular Matrix and Mineralized Osteoblast-Derived EVs Promotes Bone Regeneration via miRNA-mRNA Regulatory Axis.

Extracellular vesicles (EVs) derived from bone progenitor cells are advantageous as cell-free and non-immunogenic cargo delivery vehicles. In this study, EVs are isolated from MC3T3-E1 cells before (GM-EVs) and after mineralization for 7 and 14 days (DM-EVs). It was observed that DM-EVs accelerate the process of differentiation in recipient cells more prominently.

Global identification of mRNA-interacting circular RNAs by CLiPPR-Seq.

Although the functional role of circular RNA (circRNA) interaction with microRNAs and proteins has been studied extensively, circRNA interactions with the protein-coding mRNAs in intact cells remain largely unknown. Here, by employing AMT-mediated proximity ligation of RNA-RNA duplexes followed by circRNA enrichment and deep sequencing, we report a novel Cross-Linking Poly(A) Pulldown RNase R Sequencing (CLiPPR-seq) technology which identified hundreds of mRNA-interacting circRNAs in three different cell types, including βTC6, C2C12 and HeLa cells. Furthermore, CLiPP-seq without RNase R treatment was also performed to identify the mRNA expression in these cells.

B-P Coupling: Metal Stabilized Phosphinoborate Complexes.

In an effort to establish B-P coupling reactions without the use of phosphine-borane dehydrocoupling agent, we have developed a new synthetic methodology employing group 8 metal σ-borate complex [{κ -H,S,S'-BH L }Ru{κ -H,H,S-BH L}] (L=NC H S), 1. Treatment of 1 with chlorodiphenyl phosphine (PPh Cl) yielded 1,5-P,S chelated Ru-dihydridoborate species [PPh H{κ -H,H,S-BH(OH)L}Ru{κ -P,S-(Ph P)BH L}], 2. The insertion of phosphine moiety (PPh ) by the cleavage of 3c-2e σ(Ru H-B) bonding interaction led to the formation of B-P bond.

Glycoprotein Injectable Hydrogels Promote Accelerated Bone Regeneration through Angiogenesis and Innervation.

Glycoproteins are gaining prominence as multifunctional biomaterials. The study reports development of glycoprotein mucin as biomaterial promoting bone regeneration. Mucin 1 deletion has resulted in stiffer femoral bones with scarce presence of osteoblasts in trabecular linings and its role has been established in determining bone mass and mineralization.

Facets-Directed Epitaxially Grown Lead Halide Perovskite-Sulfobromide Nanocrystal Heterostructures and Their Improved Photocatalytic Activity.

Lead halide perovskite nanocrystal heterostructures have been extensively studied in the recent past for improving their photogenerated charge carriers mobility. However, most of such heterostructures are formed with random connections without having strong evidence of epitaxial relation. Perovskite-chalcohalides are the first in this category, where all-inorganic heterostructures are formed with epitaxial growth.

Photoelectrochemical Water Oxidation over Novel Semiconducting Zinc-Based Metal-Thiolate Framework.

Designing an efficient catalyst for a sustainable photoelectrochemical water oxidation reaction is very challenging in the context of renewable energy research. Here, we have introduced a new semiconducting porous zinc-thiolate framework via successful stitching of an "N" donor linker with a triazine-based tristhiolate secondary building unit in the overall architecture. The introduction of both linker and tristhiolate ligand synergistically modifies the architecture by making it a rigid, crystalline, three-dimensional, thermally stable, and porous framework.

Microstructural Constituents and Mechanical Properties of Low-Density Fe-Cr-Ni-Mn-Al-C Stainless Steels.

Metallic material concepts associated with the sustainable and efficient use of resources are currently the subject of intensive research. Al addition to steel offers advantages in view of lightweight, durability, and efficient use of high-Fe scrap from the Al industry. In the present work, Al was added to Fe-12Cr-(9,12)Ni-3Mn-0.

Epitaxial Orientation Angle Tuned Disk-on-Rod Nanoheterostructures for Boosting Charge Transfer.

Controlling the compositions of Se(VI) and Te(VI) ions in a 2D disk on 1D structures of Sb(V) chalcogenides, disk-on-rod heterostructures having three different epitaxial angles with different surface facets are reported. Te injection temperature determined the composition, ensuring heterostructure formation with trigonal SbSeTe disks on orthorhombic SbSe rods having orientation angles 180°, 135°, and 90°. The growth kinetics of disks connected at one/two heads of parent rods is manipulated using an Se precursor as a limiting reagent.

CsBiI nanodiscs with phase and Bi(III) state stability under reductive potential or illumination for H generation from diluted aqueous HI.

The increasingly popular, lead-free perovskite, CsBiI has a vulnerable Bi state under reductive potentials, due to the high standard reduction potential of Bi/Bi (0 < < 3). Contrary to this fundamental understanding, herein, ligand-coated CsBiI nanodiscs (NDs) demonstrate outstanding electrochemical stability with up to -1 V a saturated calomel electrode in aqueous 0.63 M (5% v/v) and 6.

Detecting RNA-RNA interactome.

The last decade has seen a robust increase in various types of novel RNA molecules and their complexity in gene regulation. RNA molecules play a critical role in cellular events by interacting with other biomolecules, including protein, DNA, and RNA. It has been established that RNA-RNA interactions play a critical role in several biological processes by regulating the biogenesis and function of RNA molecules.

Metal-Free Pyrene-Based Conjugated Microporous Polymer Catalyst Bearing N- and S-Sites for Photoelectrochemical Oxygen Evolution Reaction.

The development of an efficient, sustainable, and inexpensive metal-free catalyst for oxygen evolution reaction (OER) photoelectrochemical water splitting is very demanding for energy conversion processes such as green fuel generators, fuel cells, and metal-air batteries. Herein, we have developed a metal-free pyrene-based nitrogen and sulfur containing conjugated microporous polymer having a high Brunauer-Emmett-Teller surface area (761 m g) and a low bandgap of 2.09 eV for oxygen evolution reaction (OER) in alkaline solution.

Identification of Potential circRNA-microRNA-mRNA Regulatory Network in Skeletal Muscle.

Circular RNAs (circRNAs) are a newly discovered family of regulatory RNAs generated through backsplicing. Genome-wide profiling of circRNAs found that circRNAs are ubiquitously expressed and regulate gene expression by acting as a sponge for RNA-binding proteins (RBPs) and microRNAs (miRNAs). To identify circRNAs expressed in mouse skeletal muscle, we performed high-throughput RNA-sequencing of circRNA-enriched gastrocnemius muscle RNA samples, which identified more than 1,200 circRNAs.

Au-CuTe Plasmonic Heteronanostructure Photoelectrocatalysts.

Semiconductor nanocrystals coupled with plasmonic Au nanoparticles have been widely studied as photoelectrocatalysts for solar water splitting. Among these, heterostructures of copper chalcogenides with Au remained a unique category for their dual plasmon character. However, while sulfides and selenides of copper have been extensively reported, heterostructures of copper tellurides with Au have not been explored.

Chemically Spiraling CsPbBr Perovskite Nanorods.

Light emitting lead halide perovskite nanocrystals are currently emerging as the workhorse in quantum dot research. Most of these reported nanocrystals are isotropic cubes or polyhedral; but anisotropic nanostructures with controlled anisotropic directions still remain a major challenge. For orthorhombic CsPbBr, the 1D shaped nanostructures reported are linear and along either of the axial directions ⟨100⟩.

Emerging Role of Circular RNA-Protein Interactions.

Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA-protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs.

Doping Iron in CsPbBr Perovskite Nanocrystals for Efficient and Product Selective CO Reduction.

Lead halide perovskite nanocrystals have recently emerged as an efficient optical material for light harvesting. While these have been extensively studied for obtaining bright emissions, their use as catalysts for enhancing the rate of chemical reactions has been explored little. Considering their importance in catalysis, herein, Fe(II)-doped CsPbBr perovskite nanocrystals have been explored for photocatalytic reduction of CO.