Reduced Endothelial Progenitor Cells: A Possible Biomarker for Idiopathic Fetal Growth Restriction in Human Pregnancies.

Background: Circulating endothelial progenitor cells (EPCs) may be necessary throughout pregnancy by ensuring proper placentation and embryonic growth. The lack of standardized EPC quantification techniques has prevented conclusive proof of an increase in EPC during pregnancy.

Objectives: The purpose of this study was to determine whether EPC levels change for healthy and idiopathic fetal growth restriction (FGR) pregnancies.

Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction.

Objective: A common and serious pregnancy issue known as intrauterine growth restriction (IUGR) occurs when the fetus is unable to reach its full growth potential. Mitochondria are crucial to the development of the fetus and the placenta. We aimed to elucidate the role of oxidative stress parameters and markers of DNA damage.

Association of Maternal Serum Ischemia Modified Albumin (IMA) with Placental Histopathological Changes and Fetomaternal Outcome: A Prospective Case Control Study in Normotensive and Pre-eclamptic Women.

Introduction: Ischemia and oxidative stress leads to generation of hydroxyl free radicals and modification of '-terminus' of human serum albumin. This modified albumin molecule, known as Ischemia Modified Albumin (IMA), is elevated in early stages of ischemia. It has recently been approved by US Food and Drug Administration (US FDA) for its clinical use, as early marker of myocardial ischemia in cardiology.

Cervical gestational trophoblastic neoplasia: A rare form of gestational trophoblastic disease.

Gestational trophoblastic neoplasia (GTN) is a rare disease and is characterized by an abnormal proliferation of trophoblastic cells of placenta. Since majority of them are chemotherapy sensitive, they are one of the highly curable cancers. However, due to its varied presentation, clinicians still face many challenges in its diagnosis and management.

Association Between PON1 (L55M and Q192R) Genetic Polymorphism and Recurrent Pregnancy Loss in North Indian Women Exposed to Pesticides.

Objective:  The aim of the present study was to examine the relation between the PON1 polymorphisms and recurrent pregnancy loss (RPL).

Methods:  In a cross-sectional study, blood samples were collected from 100 females. DNA was extracted and PON1 genotypes were determined by polymerase chain reaction (PCR) amplification.

Functional and psychological evaluation of premenopausal and postmenopausal women after provision of a complete denture prosthesis.

Statement Of Problem: Clinical studies regarding satisfaction and occlusal forces with the complete denture in relation to the menopause are sparse.

Purpose: The purpose of this clinical study was to compare satisfaction levels and occlusal force with complete dentures in premenopausal and postmenopausal Indian women.

Material And Methods: Twenty premenopausal (group pre-MP) and 20 postmenopausal (group post-MP) completely edentulous participants were selected based on inclusion and exclusion criteria, and estradiol levels were measured.

Pesticide Risk and Recurrent Pregnancy Loss in Females of Subhumid Region of India.

Objective: The objective of this study is to determine the level of pesticides and their role in cases of recurrent pregnancy loss (RPL).

Materials And Methods: This was designed as a case-control study. Gas chromatography was used to characterize the pesticide level in 70 cases and 70 controls.

Comparative outcome of induced labor by intracervical Foley catheter with misoprostol versus misoprostol alone.

Aim: To evaluate the comparative outcome of induced labor by intracervical Foley catheter with misoprostol versus misoprostol alone.

Materials & Methods: A total of 1306 women were enrolled over 4 years, induced with either intracervical Foley with misoprostol or misoprostol alone and compared in terms of induction-delivery interval, mode of delivery, the presence of uterine tachysystole, postpartum hemorrhage and perinatal outcome.

Results: Induction to delivery interval, the duration between induction to active labor was significantly reduced, deliveries within 24 h were significantly higher and the number of misoprostol doses used was significantly less in Foley with misoprostol group.

Serum Vitamin D Level as a Risk Factor for Female Genital Tuberculosis (FGTB).

Introduction: Vitamin D is now known to be essential to containment and killing through activation of 25-hydroxyvitamin-D receptors (VDRs) present on all immune cells or obtained from dietary food stuffs as either vitamin D3 or vegetable vitamin D2 (also known as ergocalciferol).

Aim: To evaluate the association of serum vitamin D level between the Female Genital Tuberculosis (FGTB) cases and healthy controls.

Materials And Methods: Total 120 cases and 120 controls enrolled for the study following inclusion and exclusion criteria.

Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer.

Background: Ovarian cancer is most lethal among all gynecologic malignancies. Paclitaxel (PTX) is well used chemotherapeutic regimen for cancer control; however its undesired toxicity has been a matter of concern for clinicians. Here, we used the graphene oxide coated nanotised apigenin (GO-NA) to enhance the efficacy of paclitaxel.

MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer.

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers (mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as microRNAs (miRNAs) for cancer diagnosis and prognosis.

Association between lactate levels in vaginal fluid and time of spontaneous onset of labor in suspected cases of prelabor rupture of membranes.

Purpose: To assess correlation between lactate levels in vaginal fluid and onset of labor in suspected PROM.

Method: A prospective observational study conducted at the Dept. of Obstetrics and Gynecology and Pathology from 2008 to 2009.

Role of 677C→T polymorphism a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men.

Failure or severe difficulty in conceiving a child is surprisingly common, worldwide problem. Half of these cases are due to male factors with defects in sperm (1 in 15 men) being the single most common cause. Also about 60-75 % of male infertility cases are idiopathic, since the molecular mechanisms underlying the defects remain unknown.

Oral iron supplementation leads to oxidative imbalance in anemic women: a prospective study.

Background & Aims: This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women.

Methods: Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols.

Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis.

Objective: To understand the mechanism of action of Mucuna pruriens in the treatment of male infertility.

Design: Prospective study.

Setting: Departments of Biochemistry, Urology, and Obstetrics and Gynecology, C.

Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men.

The present investigation was undertaken to assess the role of Mucuna pruriens in infertile men who were under psychological stress. Study included 60 subjects who were undergoing infertility screening and were found to be suffering from psychological stress, assessed on the basis of a questionnaire and elevated serum cortisol levels. Age-matched 60 healthy men having normal semen parameters and who had previously initiated at least one pregnancy were included as controls.

Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men.

Objective: To investigate the impact of Mucuna pruriens seeds on semen profiles and biochemical levels in seminal plasma of infertile men.

Design: Prospective study.

Setting: Departments of Biochemistry and Obstetrics and Gynecology, King George's Medical University, Lucknow, India.