Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts.

Magnesium oxide (MgO) nanoparticles were green synthesized using mahua (Madhuca longifolia) flower extracts by solvent evaporation and characterized by UV-visible spectroscopy, X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and Energy dispersive X-ray analysis (EDX). The drug loading of sumatriptan succinate (SS), an anti-migraine drug, was optimized using MINITAB's response surface methodology (RSM) Box Behnken model (BBD) model. The investigation of drug adsorption and release kinetics was further conducted using the optimized set obtained through RSM.