Literature-based drug-drug similarity for drug repurposing: impact of Medical Subject Headings term refinement and hierarchical clustering.

We describe herein, an improved procedure for drug repurposing based on refined Medical Subject Headings (MeSH) terms and hierarchical clustering method. In the present study, we have employed MeSH data from MEDLINE (2019), 1669 US FDA approved drugs from Open FDA and a refined set of MeSH terms. Refinement of MeSH terms was performed to include terms related to mechanistic information of drugs and diseases.

Modelling and optimal control of multi strain epidemics, with application to COVID-19.

Reinfection and multiple viral strains are among the latest challenges in the current COVID-19 pandemic. In contrast, epidemic models often consider a single strain and perennial immunity. To bridge this gap, we present a new epidemic model that simultaneously considers multiple viral strains and reinfection due to waning immunity.

Lifestyle practices, health problems, and quality of life after coronary artery bypass grafting.

Introduction: Severe coronary artery disease continues to be a major health problem in India, and coronary artery bypass grafting (CABG) is the accepted modality of treatment. Post-operative long-term quality of life depends on the healthy lifestyle practices and appropriate control of risk factors. We tried to bring out the patient awareness and their practices after the surgery and their implications on their quality of life (QOL).

Numerical modeling of mosquito population dynamics of Aedes aegypti.

Background: The global incidences of dengue virus have increased the interest in studying and understanding the mosquito population dynamics. It is predominantly spread by Aedes aegypti in the tropical and sub-tropical countries in the world. Understanding these dynamics is important for public health in countries where climatic and environmental conditions are favorable for the propagation of these diseases.

Prevalence and Patterns of Learning Disabilities in School Children.

Objective: To assess the prevalence and patterns of learning disabilities (LD) in school going children in a northern city of India.

Methods: The present cross-sectional study comprised of three-staged screening procedure for assessing learning disabilities of 3rd and 4th grade students studying in government schools. The first stage comprised of the teacher identifying at-risk student.

Perceptions of teachers about learning disorder in a northern city of India.

Background: Teachers are perhaps the closest observers of child's academic performance and can be instrumental in detecting learning disorder (LD) early.

Objectives: The present study aimed to assess the teachers' perceptions about LD.

Materials And Methods: This is a cross-sectional questionnaire-based study in the public schools located in the urban, rural and slum areas of Chandigarh.