Publications by authors named "Shweta Venkataraman"

Article Synopsis
  • Inflammasome proteins, like NLRC4, play a role in controlling inflammation and cell death, but also impact diseases in ways other than their typical functions.
  • Research shows that NLRC4 can help reduce tumor development in a specific mouse model, independently of other inflammasome proteins.
  • NLRC4 works with a complex involved in DNA damage response, promoting mechanisms that activate checkpoint proteins to prevent cancer by managing DNA damage effectively.*
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Biobanking of patient-derived specimens offers unique opportunities for retrospective testing that could potentially contribute to diagnosing and evaluating clinical conditions, advancing personalized medicine and translational biomedical discovery. In this protocol, we detail the collection, processing, and cryopreservation of peripheral blood, bone marrow, and lymph nodes from patients with hematological malignancies. This protocol can be used for multiomics to gain cellular and molecular insights into blood cancers and to test the therapeutic potential of compounds for translational biomedical research.

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The innate immune response contributes to the development or attenuation of acute and chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged host cells can activate different host responses that shape disease outcomes. Here, we show that mice and humans lacking a single allele of the DNA repair protein Ku70 had increased susceptibility to the development of intestinal cancer.

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