Publications by authors named "Shweta Dhanda"
Article Synopsis
- Johne's disease (JD), caused by the bacterium MAP, significantly impacts cattle health, which in turn affects the livestock industry globally.
- A comprehensive meta-analysis of 21 studies revealed a 16% prevalence of paratuberculosis in cows via milk ELISA and 8% via serum ELISA, with regional variations in confidence intervals noted.
- The results highlight the need for improved diagnostic strategies, providing critical information for veterinarians and livestock producers to better manage the disease.
Since 2019, Lumpy skin disease (LSD) has suddenly spread in many Asian countries, including India. LSD primarily occurs in cattle. However, recent LSD outbreaks in India have also revealed significant morbidity and production losses in buffaloes.
View Article and Find Full Text PDFsubspecies (MAP) infection leads to chronic, persistent granulomatous enteritis, causing prolonged diarrhoea and emaciation. The disease is managed using medications such as antibiotics, live vaccines, mycobacteriophage therapies and other treatments; however, a notable proportion of affected animals do not show improvement with this approach. We hypothesise that immunoinhibitory receptors TIM-3 (T cell immunoglobulin mucin protein-3) and PD-1 (Programmed death receptor 1) may be upregulated on Peripheral blood mononuclear cells (PBMCs) of MAP-seropositive bovines, potentially contributing to immune exhaustion.
View Article and Find Full Text PDFArticle Synopsis
- miRNAs, specifically miR-29a, play a crucial role in regulating immune responses in cattle, particularly in the context of LSDV infection.
- Inhibition of miR-29a leads to increased IFN-γ production, enhancing the activation of CD8+ T cells and facilitating virus clearance.
- Rathi cattle show a stronger immune response to LSDV compared to crossbred cattle, with lower miR-29a levels correlating to a more effective cell-mediated immune response.