20 µm resolution multipixel ghost imaging with high-energy x-rays.

Hard x-ray imaging is indispensable across diverse fields owing to its high penetrability. However, the resolution of traditional x-ray imaging modalities, such as computed tomography (CT) systems, is constrained by factors including beam properties, the limitations of optical components, and detection resolution. As a result, the typical resolution in commercial imaging systems that provide full-field imaging is limited to a few hundred microns, and scanning CT systems are too slow for many applications.

Synchrotron-based x ray fluorescence ghost imaging.

X ray fluorescence ghost imaging (XRF-GI) was recently demonstrated for x ray lab sources. It has the potential to reduce the acquisition time and deposited dose by choosing their trade-off with a spatial resolution while alleviating the focusing constraints of the probing beam. Here, we demonstrate the realization of synchrotron-based XRF-GI: we present both an adapted experimental setup and its corresponding required computational technique to process the data.

Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer.

The third leading cause of cancer-related deaths in the United States is pancreatic cancer, more than 95% of which is pancreatic ductal adenocarcinoma (PDA). The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25% are eligible. Tumor recurrence and metastasis are the main causes of cancer-related mortality.

Overexpression of MUC1 Induces Non-Canonical TGF-β Signaling in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. Transforming Growth Factor Beta (TGF-β) is a cytokine that switches from a tumor-suppressor at early stages to a tumor promoter in the late stages of tumor development, by yet unknown mechanisms. Tumor associated MUC1 is aberrantly glycosylated and overexpressed in >80% of PDAs and is associated with poor prognosis.

Efficient Interaction of Heralded X-Ray Photons with a Beam Splitter.

We report the experimental demonstration of efficient interaction of multi-kilo-electron-volt heralded x-ray photons with a beam splitter. The measured heralded photon rate at the outputs of the beam splitter is about 0.01  counts/s which is comparable to the rate in the absence of the beam splitter.

X-ray imaging of fast dynamics with single-pixel detector.

We demonstrate experimentally the ability to use a single-pixel detector for two-dimensional high-resolution x-ray imaging of fast dynamics. We image the rotation of a spinning chopper at 100 kHz and at spatial resolution of about 40 microns by using the computational ghost imaging approach. The technique we develop can be used for the imaging of fast dynamics of periodic and periodically stimulated effects with a large field of view and at low dose.

Subattosecond x-ray Hong-Ou-Mandel metrology.

We show that subattosecond delays and subangstrom optical path differences can be measured by using Hong-Ou-Mandel interference measurements with x-rays. Our scheme relies on the subattosecond correlation time of photon pairs that are generated by x-ray spontaneous parametric down-conversion, which leads to a dip in correlation measurements with a comparable width. Therefore, the precision of the measurements is expected to be better than 0.

The Behavior Rating Inventory of Executive Function®-Adult Version is Related to Emotional Distress, Not Executive Dysfunction, in a Veteran Sample.

Objective: In three studies, we explore the impact of response bias, symptom validity, and psychological factors on the self-report form of the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) and the relationship between self-reported executive functioning (EF) and objective performance.

Method: Each study pulled from a sample of 123 veterans who were administered a BRIEF-A and Minnesota Multiphasic Personality Inventory-2 (MMPI-2) during a neuropsychological evaluation. Participants were primarily middle-aged, and half carried a mood disorder diagnosis.

Observation of strong nonlinear interactions in parametric down-conversion of X-rays into ultraviolet radiation.

Nonlinear interactions between X-rays and long wavelength radiation can be used as a powerful atomic-scale probe for light-matter interactions and for properties of valence electrons. However, reported X-ray nonlinear effects were small and their observations required tremendous efforts. Here we report the observation of strong nonlinearities in parametric down-conversion (PDC) of X-rays to long wavelength radiation in gallium arsenide and lithium niobate crystals, with efficiencies about 4 orders of magnitude stronger than the efficiencies measured in any material studied before.

X-ray computational ghost imaging with single-pixel detector.

We demonstrate computational ghost imaging at X-ray wavelengths with only one single-pixel detector. We show that, by using a known designed mask as a diffuser that induces intensity fluctuations in the probe beam, it is possible to compute the propagation of the electromagnetic field in the absence of the investigated object. We correlate these calculations with the measured data when the object is present in order to reconstruct the images of 50 μm and 80 μm slits.

Evidence for Collective Nonlinear Interactions in X Ray into Ultraviolet Parametric Down-Conversion.

We present the observation of peculiar nonmonotonic photon energy dependencies of the count rates and of the rocking curves of parametric down-conversion of x rays into ultraviolet far from any atomic resonances. The observations cannot be explained by models that consider only atomic or bond charge responses and suggest that collective phenomena contribute to the effect. We propose an interpretation that includes nonlinear interactions with plasmons, which can explain the existence of peaks in this energy range.

Parametric Down-Conversion of X Rays into the Optical Regime.

We report the observation of parametrically down-converted x-ray signal photons at photon energies that correspond to idler photons at optical wavelengths. The count-rate dependence on the angles of the input beam and of the detector and on the slit sizes agrees with theory within the experimental uncertainties. The nonlinear susceptibility, which we calculated from the measured efficiencies, is comparable to the nonlinear susceptibility evaluated from the measurements of x-ray and optical wave mixing.

Psychometric properties of the Saint Louis University Mental Status Examination.

The Saint Louis University Mental Status (SLUMS) Examination is a brief screening measure for mild neurocognitive disorder developed for use with veterans. To date, there has been a paucity of research on its psychometric properties. The purpose of this study is to evaluate the psychometric properties of the SLUMS in a referred sample to a specialty clinic.

X-ray ghost imaging with a laboratory source.

We describe an experiment demonstrating ghost imaging with an incoherent low brightness X-ray tube source. We reconstruct the images of 10 μm and 100 μm slits with very high contrast. Our results advance the possibilities that the high-resolution method of ghost diffraction will be utilized with tabletop X-ray sources.

Difference-frequency generation of optical radiation from two-color x-ray pulses.

We describe the process of difference-frequency generation of short optical pulses from two-color X-ray pulses. By assuming 10¹¹ photons per X-ray pulse, we predict that the optical count rate can exceed 10⁷ photons per pulse. Similar to other effects involving nonlinear interactions of X-rays and optical radiation, the effect we describe can be used for microscopic studies of chemical bonds and as a probe for light-matter interactions on the atomic scale.

X-ray second harmonic generation.

We report clear experimental evidence for second harmonic generation at hard x-ray wavelengths. Using a 1.7 Å pumping beam generated by a free electron laser, we observe second harmonic generation in diamond.

Diffractive optical elements for mode-division multiplexing of temporal signals with the aid of Laguerre-Gaussian modes.

Optical aspects of space-division multiplexing with orthogonal modes of coherent light were considered in theory and experiments with the coherent optical correlator. We resorted to the mathematical tool of generating functions and technologies of diffractive optical elements to implement complex spatial filters matched to rotationally symmetrical transverse modes. Successful multiplexing and demultiplexing in free-space transmission of low-frequency temporally modulated signals through different spatial modes was demonstrated.

X-ray parametric down-conversion in the Langevin regime.

We experimentally and theoretically study the coincidence count rate for down-converted x-ray photons. Because of photoionization, parametric down-conversion at x-ray wavelengths generally involves loss and the theoretical description requires a Langevin approach. By working in a transmission geometry (Laue) rather than in the Bragg geometry of previous experiments, we obtain an improvement in the signal-to-noise ratio of 12.

X-ray and optical wave mixing.

Light-matter interactions are ubiquitous, and underpin a wide range of basic research fields and applied technologies. Although optical interactions have been intensively studied, their microscopic details are often poorly understood and have so far not been directly measurable. X-ray and optical wave mixing was proposed nearly half a century ago as an atomic-scale probe of optical interactions but has not yet been observed owing to a lack of sufficiently intense X-ray sources.

Polarization entangled photons at x-ray energies.

We show that polarization entangled photons at x-ray energies can be generated via spontaneous parametric down-conversion. Each of the four Bell states can be generated by choosing the angle of incidence and polarization of the pumping beam.

Skyless polarimetric calibration and visibility enhancement.

Outdoor imaging in haze is plagued by poor visibility. A major problem is spatially-varying reduction of contrast by airlight, which is scattered by the haze particles towards the camera. However, images can be compensated for haze, and even yield a depth map of the scene.

Ordered subset expectation maximization and wide beam reconstruction "half-time" gated myocardial perfusion SPECT functional imaging: a comparison to "full-time" filtered backprojection.

Objectives: Compared to filtered back projection (FBP), OSEM with resolution recovery (OSEM-RR) and wide beam reconstruction (WBR)(UltraSPECT Ltd.), which resolve resolution and suppress noise simultaneously during reconstruction, have been shown to maintain/improve myocardial perfusion SPECT quality, even with low count density half-time acquisitions. We postulated that their characteristics would be advantageous for gated SPECT, where each frame is only 1/8th the count density of the summed perfusion images.

Photorefractive solitons and light-induced resonance control in semiconductor CdZnTe.

We demonstrate the formation of (1+1) - and (2+1) -dimensional solitons in photorefractive CdZnTe:V, exploiting the intensity-resonant behavior of the space-charge field. We control the resonance optically, facilitating a 10-mus soliton formation times with very low optical power.

Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies.

Background: Newly developed reconstruction algorithms enable the acquisition of images at half of the scan time while maintaining image quality. The purpose of this investigation was to evaluate a novel wide beam reconstruction (WBR) method developed by UltraSPECT for decreasing scan times and to compare it with filtered backprojection (FBP), which is the technique routinely used.

Methods And Results: Phantom and clinical studies were performed.