Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?

Background: Chronic myelogenous leukemia (CML) is a hematopoietic stem cell disorder. It is associated with acquired genetic changes in the hematopoietic stem cells in the form of BCR-ABL fusion gene also known as Philadelphia chromosome.

Materials And Methods: We prospectively studied thyroid function at baseline and at 6 months of imatinib treatment in 26 newly diagnosed BCR-ABL positive CML patients.

Transbuccal Approach in Management of Mandible Angle Fracture.

With expanding dimensions and an eminent member of trauma team many Ear Nose Throat specialists are exposed to Oro-maxillofacial trauma. Mandibular angle is a difficult region to operate owing to its unique anatomy. Anglefractures form around 30-40% of the mandibular fracture.

Machine vision based alternative testing approach for physical purity, viability and vigour testing of soybean seeds ().

The conventional methods for seed quality testing have several limitations as they involve visual assessment and are destructive. In this context, a study was performed to assess the suitability of non-contact, non-destructive type imaging techniques such as visible imaging and X-ray imaging for conducting physical purity, viability and vigour tests of soybean seeds. The seeds that appeared healthy in external surface examination using visible tests as well as in internal assessment using X-ray tests were classified as sound seeds while the other seeds were marked as not-sound seeds.

ROP and ATRP Fabricated Dual Targeted Redox Sensitive Polymersomes Based on pPEGMA-PCL-ss-PCL-pPEGMA Triblock Copolymers for Breast Cancer Therapeutics.

To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes based on redox sensitive amphiphilic triblock copolymer poly(polyethylene glycol methacrylate)-poly(caprolactone)-s-s-poly(caprolactone)-poly(polyethylene glycol methacrylate) (pPEGMA-PCL-ss-PCL-pPEGMA) with disulfide linkage were designed and developed. The polymers were synthesized by ring opening polymerization (ROP) of ε-caprolactone followed by atom transfer radical polymerization (ATRP) of PEGMA. The triblock copolymers demonstrated various types of nanoparticle morphologies by varying hydrophobic/hydrophilic content of polymer blocks, with PEGMA content of ∼18% in the triblock copolymer leading to the formation of polymersomes in the size range ∼150 nm.

Comparative Evaluation of the Complementary and Alternative Medicine Therapy and Conventional Therapy Use for Musculoskeletal Disorders Management and Its Association with Job Satisfaction among Dentists of West India.

Musculoskeletal problems have become a significant issue in the profession of dentistry. There are currently no recommended effective disease-preventing and modifying remedies. High prevalence rates for musculoskeletal disorders (MSDs) among dentists have been reported in the literature.

Preparation and in vitro evaluation of folate-receptor-targeted SPION-polymer micelle hybrids for MRI contrast enhancement in cancer imaging.

Polymer-SPION hybrids were investigated for receptor-mediated localization in tumour tissue. Superparamagnetic iron oxide nanoparticles (SPIONs) prepared by high-temperature decomposition of iron acetylacetonate were monodisperse (9.27 ± 3.

Intraoral superficial angiomyxoma of the upper alveolus: report of a unique case.

Angiomyxomas are relatively a group of uncommon myxoid mesenchymal tumors characterized by frequent local recurrences and show lack of malignant potential. Basically three types of angiomyxomas are recognized superficial, aggressive, and angiomyofibroblastoma. Though the angiomyxomas are rarely reported in the head and neck region, the paper shows reported cases intraorally in the buccal mucosa and floor of the mouth.