Trace-elements driven up-regulation of secreted proteases expression in the human-pathogenic fungus Trichophyton rubrum.

Background: Trichophyton rubrum is a widespread human pathogenic fungus, colonizing keratinized tissue of outer body-parts. Thereby, the pathogen is relying on nutrients available from the host. The invasive mechanism of the pathogen is relaying on secreted proteases, which hydrolyze skin-proteins for subsequent up-take.

Elemental Geochemical Characteristics of Shales from Wufeng-Longmaxi Formations in the Southern Margin of the Qinling Orogenic Belt, China: Implications for Depositional Controls on Organic Matter.

The tectonic background and sedimentary environment during the transition period from the Ordovician to Silurian have been widely studied by many scholars. This study focuses on the Upper Ordovician Wufeng Formation and Lower Silurian Longmaxi Formation in the Bajiaokou profile at the southern margin of the Qinling Orogenic Belt in southern China. In order to study the aggregation mechanism of organic matter, geochemical proxies were proposed, including redox proxies (V, V/Al, U, U/Al, Mo, and Mo/Al), paleoproductivity proxies (P, P/Ti, Ba, Ba/Al, and Si), paleoclimate proxies (CIA), and terrigenous flux proxies (Al, Zr, and Zr/Al).

Expression Profiles of Protease in Onychomycosis-Related Pathogenic Trichophyton rubrum and Tinea Capitis-Related Pathogenic Trichophyton violaceum.

The two fungal species Trichophyton rubrum and Trichophyton violaceum are common pathogens on human, infecting keratinized tissue of the outer body parts. Both species are belonging to the "Trichophyton rubrum complex" and share very high similarity in the genome. Secreted proteinases, key factors for keratin degradation, are nearly identical.

Rare Earth Element Characteristics of Shales from Wufeng-Longmaxi Formations in Deep-Buried Areas of the Northern Sichuan Basin, Southern China: Implications for Provenance, Depositional Conditions, and Paleoclimate.

To explore the sedimentary environment and the background of the source area of organic-rich shales in the Wufeng-Longmaxi Formations in the northern Sichuan Basin, samples from Well XX1 in the area were subjected to geochemical testing and analysis of organic carbon content, trace elements, and rare earth elements (REEs). The results show that the total content of REE (ΣREE) of the shale in the Wufeng-Longmaxi Formations varied from 183.08 to 234.

Construction and validation of cognitive frailty risk prediction model for elderly patients with multimorbidity in Chinese community based on non-traditional factors.

Background And Objectives: Early identification of risk factors and timely intervention can reduce the occurrence of cognitive frailty in elderly patients with multimorbidity and improve their quality of life. To explore the risk factors, a risk prediction model is established to provide a reference for early screening and intervention of cognitive frailty in elderly patients with multimorbidity.

Methods: Nine communities were selected based on multi-stage stratified random sampling from May-June 2022.

Geochemical Changes in the Late Ordovician to Early Silurian Interval in the Northern Margin of the Upper Yangtze Platform, Southern China: Implications for Hydrothermal Influences and Paleocean Redox Circumstances.

A comprehensive chemostratigraphic study, including evaluation of rare earth elements and trace elements, was conducted to explain the paleoenvironments of the northern margin of the Upper Yangtze Platform. Trace elements, like Ba, U, V, Cu, and Zn, tended to be more abundant in these formations than in the upper continental crust. The authigenic abundances of Al-normalized U and V, as well as the Th/U and V/Sc ratios, were used as indicators of the redox circumstances.

Differential deuterolysin expression with a peak at low pH in human pathogenic fungi Trichophyton rubrum and T. mentagrophytes.

Trichophyton rubrum and T. mentagrophytes are the most common agents of dermatomycosis, a disease affecting millions worldwide. It has been widely recognized that secreted proteases are a key factor for host colonization.