Carbon dioxide (CO) electroreduction has extraordinary significance in curbing CO emissions while simultaneously producing value-added chemicals with economic and environmental benefits. In recent years, breakthroughs in designing catalysts, optimizing intrinsic activity, developing reactors, and elucidating reaction mechanisms have continuously driven the advancement of CO electroreduction. However, the industrialization of CO electroreduction remains a challenging task, with high energy consumption, high costs, limited reaction products, and restricted application scenarios being the issues that urgently need to be addressed.
View Article and Find Full Text PDFSegmenting the irregular pancreas and inconspicuous tumor simultaneously is an essential but challenging step in diagnosing pancreatic cancer. Current deep-learning (DL) methods usually segment the pancreas or tumor independently using mixed image features, which are disrupted by surrounding complex and low-contrast background tissues. Here, we proposed a deep causal learning framework named CausegNet for pancreas and tumor co-segmentation in 3D CT sequences.
View Article and Find Full Text PDFBackground: Scientific research activity in hospitals is important for promoting the development of clinical medicine, and the scientific literacy of medical staff plays an important role in improving the quality and competitiveness of hospital research. To date, no index system applicable to the scientific literacy of medical staff in China has been developed that can effectively evaluate and guide scientific literacy. This study aimed to establish an index system for the scientific literacy of medical staff in China and provide a reference for improving the evaluation of this system.
View Article and Find Full Text PDFThe applications of silica-based glass have evolved alongside human civilization for thousands of years. High-precision manufacturing of three-dimensional (3D) fused silica glass objects is required in various industries, ranging from everyday life to cutting-edge fields. Advanced 3D printing technologies have emerged as a potent tool for fabricating arbitrary glass objects with ultimate freedom and precision.
View Article and Find Full Text PDFInvestigating correlations between radiomic and genomic profiling in breast cancer (BC) molecular subtypes is crucial for understanding disease mechanisms and providing personalized treatment. We present a well-designed radiogenomic framework image-gene-gene set (IMAGGS), which detects multi-way associations in BC subtypes by integrating radiomic and genomic features. Our dataset consists of 721 patients, each of whom has 12 ultrasound (US) images captured from different angles and gene mutation data.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
October 2023
Electrochemical CO reduction to value-added chemicals or fuels offers a promising approach to reduce carbon emissions and alleviate energy shortage. Cu-based electrocatalysts have been widely reported as capable of reducing CO to produce a variety of multicarbon products (e.g.
View Article and Find Full Text PDFBreast Cancer (Dove Med Press)
July 2023
Purpose: The emergence of genomic targeted therapy has improved the prospects of treatment for breast cancer (BC). However, genetic testing relies on invasive and sophisticated procedures.
Patients And Methods: Here, we performed ultrasound (US) and target sequencing to unravel the possible association between US radiomics features and somatic mutations in TNBC (n=83) and non-TNBC (n=83) patients.
Proximity labeling has emerged as a powerful strategy for interrogating cell-cell interactions. However, the nanometer-scale labeling radius impedes the use of current methods for indirect cell communications and makes recording cell spatial organization in tissue samples difficult. Here, we develop quinone methide-assisted identification of cell spatial organization (QMID), a chemical strategy with the labeling radius matching the cell dimension.
View Article and Find Full Text PDFHigh-resolution patterning of perovskite quantum dots (PQDs) is of significant importance for satisfying various practical applications, including high-resolution displays and image sensing. However, due to the limitation of the instability of PQDs, the existing patterning strategy always involves chemical reagent treatment or mask contact that is not suitable for PQDs. Therefore, it is still a challenge to fabricate high-resolution full-color PQD arrays.
View Article and Find Full Text PDFPatterned quantum dots (QDs) and perovskites have attracted a great deal of attention in the fabrication of optoelectronic device arrays for transistors, image sensors and displays. However, the resolution of current patterning technologies is insufficient for nanopatterned QDs and perovskites to be integrated in advanced optoelectronic and photonic applications. Herein, we demonstrate a femtosecond laser regulatory focus ablation (FsLRFA) patterning technique of a fluorescent film involving both semiconductor core-shell QDs and perovskite up to 1/10th of the scale of the diffraction limit.
View Article and Find Full Text PDFSelf-renewal and differentiation of embryonic stem cells (ESCs) are influenced by protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification, but the underlying mechanism remains incompletely understood. Herein, we report the identification of 979 O-GlcNAcylated proteins and 1340 modification sites in mouse ESCs (mESCs) by using a chemoproteomics method. In addition to OCT4 and SOX2, the third core pluripotency transcription factor (PTF) NANOG was found to be modified and functionally regulated by O-GlcNAc.
View Article and Find Full Text PDFFemtosecond laser ablation (FsLA) technology has been demonstrated to achieve programmable ablation and removal of diverse materials with high precision. Owing to the cross-scale and digital processing characteristics, the FsLA technology has attracted increasing interest. However, the moderate repeatability of FsLA limits its application in the fabrication of advanced micro-/nanostructures due to the nonidentity of each laser pulse and fluctuation of environment.
View Article and Find Full Text PDFAs an essential micronutrient element in organisms, copper controls a host of fundamental cellular functions. Recently, copper-dependent cell growth and proliferation have been defined as "cuproplasia". Conversely, "cuproptosis" represents copper-dependent cell death, in a nonapoptotic manner.
View Article and Find Full Text PDFOrganic semiconductor single crystal materials have broad application prospects in the field of high-performance optoelectronic devices because of their highly ordered structure, few defects, and high carrier mobility. However, it is difficult to control the nucleation location of crystal formation in the current commonly used crystal growth methods including physical vapor transport and solution processing, which makes it difficult to manufacture organic crystal devices. Laser-induced crystallization technology is expected to solve this problem.
View Article and Find Full Text PDFMetal halide perovskites have exhibited promising potential for practical applications such as image sensors and displays benefiting from their outstanding optoelectronic properties. However, owing to the instability of the perovskite materials, producing patterned perovskite films with adequately high quality and high precision for such practical applications poses a challenge for existing patterning methods. Herein, the lamination-assisted femtosecond laser ablation (LA-FsLA) technique was successfully applied to fabricate patterned CsPbBr films with sufficiently high quality and high precision.
View Article and Find Full Text PDFConductive polymers have attracted a great deal of attention due to their remarkable electrical conductivity. However, the low solubility and inability to meet the limit for the flexible patterning fabrication ability of conductive polymers hinders their applications in miniaturized and integrated electronic devices. Here, femtosecond laser direct writing (FsLDW) is employed to achieve the in situ fabrication of polypyrrole (PPy) with flexibility.
View Article and Find Full Text PDFAs a typical class of excited-state intramolecular proton transfer (ESIPT) molecules, 3-hydroxyflavone derivatives (3HF, also known as flavonols) have received much attention recently. Thereinto, the role of hydrophobic microenvironment is significant importance in promoting the process and effects of ESIPT, which can be regulated by the solvents, the existence of metal ions and proteins rich with α-helix structures or the advanced DNA structures. Considering that plenty of biological macromolecules offer cellular hydrophobic microenvironment, enhancing the ESIPT effects and resulting in dual emission, 3HF could be a promising scaffold for the development of fluorescent imaging in cells.
View Article and Find Full Text PDFTau is a microtubule-associated protein widely distributed in the central nervous system (CNS). The main function of tau is to promote the assembly of microtubules and stabilize their structure. After a long period of research on neurodegenerative diseases, the function and dysfunction of the microtubule-associated protein tau in neurodegenerative diseases and tau neurotoxicity have attracted increasing attention.
View Article and Find Full Text PDFColloidal quantum dots (QDs) have exhibited great potential for optoelectronic applications, including displays, lasers, anti-counterfeiting and information storage. However, the high-resolution patterning technique of QDs is still a challenge, while precise patterned QDs are of great value for practical applications. Here, a femtosecond laser direct writing strategy was demonstrated for the fabrication of high-resolution-patterned perovskite quantum dots (PQDs) by the laser-induced Marangoni flow to aggregate and deposit the PQDs based on the opto-thermoelectric mechanism.
View Article and Find Full Text PDFWith the ever-increasing sophistication of integration of electronic devices, the problem of heat accumulation has become ever more serious. Here, a miniaturized photodetector with thermal stability was fabricated by combining the excellent characteristics of femtosecond laser direct writing (FsLDW) and silicon (Si). The sensing part of the photodetector is a Si microwire composed of Si nanoparticles and the sensing area is only 300 μm.
View Article and Find Full Text PDFElectrochemical CO reduction to value-added chemicals/fuels provides a promising way to mitigate CO emission and alleviate energy shortage. CO -to-CO conversion involves only two-electron/proton transfer and thus is kinetically fast. Among the various developed CO -to-CO reduction electrocatalysts, transition metal/N-doped carbon (M-N-C) catalysts are attractive due to their low cost and high activity.
View Article and Find Full Text PDFDigital manufacturing technology meets the needs of today's technological development. However, the post-processing is essential for some digital fabrication methods, such as annealing and ultraviolet (UV) exposure. Femtosecond laser direct writing (FsLDW) has gained considerable attention, because it is a non-photolithographic, non-vacuum, and no heat fabrication method.
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