Copper-based fluorescent nanozyme used to construct a ratiometric sensor for visual detection of thiophanate methyl.

Although nanozyme has shown great potential in designing fluorescent assays for pesticide residue, most of them are based on single emission, thus affecting the detection accuracy. Herein, a copper-based fluorescent nanozyme (Cu-BH) synthesized with dual-ligand, integrating fluorescence and oxidase-mimic into one spherical nanomaterial, was used firstly to establish a ratiometric approach for visual detection of thiophanate methyl (TM). Cu-BH possesses excellent oxidase-like activities, triggering the oxidation of colorless o-phenylenediamine (OPD) into yellow luminescent products (oxOPD, λem = 564 nm).

Effects of a video intervention and ethnocultural empathy on racial color-blindness, White empathy, and willingness to confront White privilege.

Objectives: This purpose of this study was to examine (a) the effects of a video intervention on decreasing racial color-blindness, increasing White people's empathy toward racism (i.e., White empathy), and increasing willingness to confront White privilege; and (b) whether ethnocultural empathy moderated the effect of this intervention on these two outcomes.

The influence of music elements on the understanding of emotional musical meaning: based on the perspective of interval structure.

Music has become an indispensable part of people's lives, frequently encountered in various contexts of daily living. Understanding the emotional significance of music is a crucial foundation for its use. This study employed the cross-modal affective priming paradigm, combined with event-related potential technology to investigate the influence of music elements on the emotional musical meaning from the perspective of interval structure.

All-cause and cardiovascular mortality in dual sensory impairment patients: A meta-analysis of cohort studies.

Background: This meta-analysis is to determine the risk of all-cause mortality and cardiovascular mortality of dual sensory impairment (DSI).

Methods: Relevant cohort studies were searched in Medline with PubMed, Cochrane Library, and EMBASE databases. The quality of the included studies was assessed based on the Newcastle-Ottawa Quality Assessment Scale (NOS).

Ductal lavage followed by observation versus oral corticosteroids in idiopathic granulomatous mastitis: A randomized trial.

Oral corticosteroids represents the most prevalent treatment for idiopathic granulomatous mastitis. Ductal lavage with triamcinolone acetonide and antibiotics followed by observation (DL-OBS) has emerged as a novel strategy, but a comparison of them remains lacking. Here in this multicenter, open-label, non-inferiority, randomized trial (ClinicalTrials.

Regulation of LAMTOR1 by oxidative stress in retinal pigment epithelium: Implications for age-related macular degeneration pathogenesis.

Oxidative stress is a critical pathogenic factor for age-related macular degeneration (AMD). Autophagy serves as a mechanism to counteract oxidative stress. LAMTOR1 regulates mTORC1 activity by recruiting or disassembling it on the lysosome under the addition or deprivation of amino acids.

A strongly coupled oxide-support heterostructure for efficient acidic water oxidation.

The synthesized RuO/MnCoO nano-heterostructure possesses dense interfaces and abundant defect structures, synergistically balancing oxygen evolution reaction (OER) activity and stability. RuO/MnCoO exhibits a low overpotential of 190 mV at 10 mA cm. The proton exchange membrane (PEM) electrolyzer assembled can operate at 200 mA cm stably for 50 h.

Changes in overall digital structure, starch properties and moisture distribution reveal how the hardness of wheat noodles evolves under different cooking status.

To elucidate the relationship between the structural evolution of starch within noodles during cooking and the hardness, the panoramic and local microstructure of cooked noodles were quantitatively analyzed, and the structure of starch in noodles were measured. We found that in the case of starch within cooked noodles with a high degree of swelling, the quantitative analysis of each ring was sufficient to represent the structural differences. Changes occurring in starch inside noodles during cooking were not homogeneous.

Accelerated Proton Transfer in Asymmetric Active Units for Sustainable Acidic Oxygen Evolution Reaction.

The poor durability of Ru-based catalysts limits the practical application in proton exchange membrane water electrolysis (PEMWE). Here, we report that the asymmetric active units in RuMO (M = Sb, In, and Sn) binary solid solution oxides are constructed by introducing acid-resistant p-block metal sites, breaking the activity and stability limitations of RuO in acidic oxygen evolution reaction (OER). Constructing highly asymmetric Ru-O-Sb units with a strong electron delocalization effect significantly shortens the spatial distance between Ru and Sb sites, improving the bonding strength of the overall structure.

Single-molecule tip-enhanced Raman spectroscopy of C on the Si(111)-(7 × 7) surface.

Tip-enhanced Raman spectroscopy (TERS), combined with low-temperature scanning tunnelling microscopy (STM), has emerged as a highly sensitive method for chemical characterization, offering even sub-molecular resolution. However, its exceptional sensitivity is generally limited to molecules adsorbed onto plasmonic surfaces. Here we demonstrate single-molecule TERS for fullerene (C) adsorbed on the Si(111)-(7 × 7) reconstructed surface.

Comprehensive appraisal of lung function in young COPD patients: a single center observational study.

Purpose: The present study aimed to investigate the clinical characteristics and lung function impairment in young people diagnosed with chronic obstructive pulmonary disease (COPD).

Patients And Methods: We retrospectively enrolled patients with COPD who underwent symptom assessment and comprehensive pulmonary function tests at the First Affiliated Hospital of Guangzhou Medical University between August 2017 and March 2022. The patients were categorized into two groups based on age: a young COPD group (aged 20-50 years) and an old COPD group (aged > 50 years).

A New SPQC Biosensor for the Detection of a New Target of Genera Based on a Novel Method of Synthesizing Long-Range DNA.

The rapid and sensitive detection of genera is crucial for human disease and health. This study introduces a novel series of piezoelectric quartz crystal (SPQC) sensors for detecting genera. In this innovative biosensor, we propose a new target and novel method for synthesizing long-range DNA.

Development of SPQC sensor based on the specific recognition of TAL-effectors for locus-specific detection of 6-methyladenine in DNA.

N6-methyladenosine (6mA) plays a pivotal role in diverse biological processes, including cancer, bacterial toxin secretion, and bacterial drug resistance. However, to date there has not been a selective, sensitive, and simple method for quantitative detection of 6mA at single base resolution. Herein, we present a series piezoelectric quartz crystal (SPQC) sensor based on the specific recognition of transcription-activator-like effectors (TALEs) for locus-specific detection of 6mA.

Ultrasensitive Detection of Tumor Suppressor Gene Methylation by Piezoelectric Sensing Based on Enrichment of Transcription Activator-Like Effectors.

The detection of DNA methylation at cytosine/guanine dinucleotide (CpG) islands in promoter regions of tumor suppressor genes has great potential for early cancer screening, diagnosis, and prognosis monitoring. Nevertheless, achieving accurate, sensitive, cost-effective, and quantitative detection of target methylated DNA remains challenging. Herein, we propose a novel piezoelectric sensor (series piezoelectric quartz crystal (SPQC)) based on transcription activator-like effectors (TALEs) for detecting DNA methylation of Ras association domain family 1 isoform A (RASSF1A) tumor suppressor genes (R-5mC).

Passivation of Sodium Benzenesulfonate at the Buried Interface of a High-Performance Wide-Bandgap Perovskite Solar Cell.

The phase segregation of wide-bandgap perovskite is detrimental to a device's performance. We find that Sodium Benzenesulfonate (SBS) can improve the interface passivation of PTAA, thus addressing the poor wettability issue of poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine](PTAA). This improvement helps mitigate interface defects caused by poor contact between the perovskite and PTAA, reducing non-radiative recombination.

Characterization of the biological and transcriptomic landscapes of bone marrow-derived mesenchymal stem cells in patients with multiple myeloma.

Background: Mesenchymal stem/stromal cells (MSCs) have been acknowledged as the most important stromal cells in the bone marrow (BM) microenvironment for physiologic hematopoiesis and the concomitant hematologic malignancies. However, the systematic and detailed dissection of the biological and transcriptomic signatures of BM-MSCs in multiple myeloma (MM) are largely unknown.

Methods: In this study, we isolated and identified BM-MSCs from 10 primary MM patients and 10 healthy donors (HD).

Cell reprogramming therapy for Parkinson's disease.

Parkinson's disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Many studies have been performed based on the supplementation of lost dopaminergic neurons to treat Parkinson's disease. The initial strategy for cell replacement therapy used human fetal ventral midbrain and human embryonic stem cells to treat Parkinson's disease, which could substantially alleviate the symptoms of Parkinson's disease in clinical practice.

Echo-Level SAR Imaging Simulation of Wakes Excited by a Submerged Body.

The paper introduces a numerical simulation method for Synthetic Aperture Radar (SAR) imaging of submerged body wakes by integrating hydrodynamics, electromagnetic scattering, and SAR imaging simulation. This work is helpful for better understanding SAR images of submerged body wakes. Among these, the hydrodynamic model consists of two sets of ocean dynamics closely related to SAR imaging, namely the wake of the submerged body and wind waves.