Ectopic pregnancy is associated with increased risk of displaced implantation window: a retrospective study.

Background: To evaluate the risk factors associated with WOI (window of implantation) displacement based on ERT (endometrial receptivity test), and to confirm the association of ectopic pregnancy with WOI displacement.

Methods: This is a retrospective study at the Reproductive Medicine Center of Xiangya Hospital from January 2020 to April 2024, consisting of 934 patients who performed ERT. The patients underwent 3771 assisted reproductive technology (ART) cycles and 2629 embryo transfer (ET) cycles, with each patient experiencing at least one implantation failure.

Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy.

Tissue-resident memory T (T) cells preferentially reside in peripheral tissues, serving as key players in tumor immunity and immunotherapy. The lack of effective approaches for expanding T cells and delivering these cells in vivo hinders the exploration of T cell-mediated cancer immunotherapy. Here, we report a nanoparticle artificial antigen-presenting cell (nano-aAPC) ex vivo expansion approach and an in vivo delivery system for T cells.

PRMT1 Promotes the Self-renewal of Leukemia Stem Cells by Regulating Protein Synthesis.

The application of tyrosine kinase inhibitors (TKIs) has revolutionized the management of chronic myeloid leukemia (CML). However, disease relapse and progression particularly due to persistent leukemia stem cells (LSCs) remain a big challenge in the clinic. Therefore, validation of the therapeutic vulnerability in LSCs is urgently needed.

Fluorescence enhancement of cyanine/hemicyanine dyes with adamantane as an auxochrome through host-guest inclusion with methylated cyclodextrin in water.

Fluorescence of cyanine dyes is often quenched in aqueous solution, limiting their application in water or biological system. In this work, a novel strategy of host-guest interaction based on cyanine derivatives containing auxochromes was proposed to enhance fluorescence in aqueous solution and cell imaging. By using the host (methylated β-cyclodextrin, M-β-CD) to inclusion and suppress the TICT effect of the dye, the fluorescence was significantly enhanced at lower host concentration.

Continuous vital sign monitoring on surgical wards: The COSMOS pilot.

Study Objectives: Alerts for vital sign abnormalities seek to identify meaningful patient instability while limiting alarm fatigue. Optimal vital sign alarm settings for postoperative patients remain unknown, as is whether alerts lead to effective clinical responses reducing vital sign disturbances. We conducted a 2-phase pilot study to identify thresholds and delays and test the hypothesis that alerts from continuous monitoring reduce the duration of vital sign abnormalities.

Fabrication and characterization of double-layer active intelligent film based on chitosan, polyvinyl alcohol, grape skin anthocyanin and selenium nanoparticle.

This study involved the fabrication of double-layer intelligent films using chitosan (CS), polyvinyl alcohol (PVA), grape skin anthocyanin (GSA), gellan gum (GG) and selenium nanoparticles (SeNPs). The CS/PVA/GSA layer functioned as the internal indicator layer, and the GG/SeNPs layer acted as the external layer for antioxidant and antimicrobial purposes. SEM, FTIR, XRD, and TGA results confirmed the successful fabrication of double-layer films as well as the presence of hydrogen bonding interaction between the two layers.

Predicting Preoperative Pathologic Grades of Bladder Cancer Using Intravoxel Incoherent Motion and Amide Proton Transfer-Weighted Imaging.

Rationale And Objectives: To investigate the predictive value of intravoxel incoherent motion (IVIM) combined with amide proton transfer-weighted (APTw) imaging for the preoperative grading of bladder cancer (BC).

Materials And Methods: A total of 69 patients with histopathologically confirmed BC underwent diffusion-weighted imaging (DWI), IVIM, and APTw imaging at 3.0 T MRI.

Reducing the oil absorption and oil deterioration in fried apple slices by ultrasound integrated in infrared frying.

The effects of integrated ultrasonic infrared frying (USIF) on the oil absorption of apple slices and the oil deterioration were studied with frequency of 28 and 40 kHz, respectively. Results showed that the heat transfer and moisture migration was accelerated by the integrated ultrasound in IF. The soluble Gal-A content and esterification degree of pectin was increased, the damages of pectin crystal structure and chemical structure in side chain was aggravated.

Recovery of Selenium-Enriched Polysaccharides from Residues: Comparison on Structure and Antioxidant Activity by Different Extraction Methods.

The residues from selenium-enriched after the extraction of protein were still rich in polysaccharides. Thus, the recovery of selenium polysaccharides (SePSs) was compared using hot water extraction and ultrasonic-assisted extraction techniques. The yield, extraction rate, purity, specific energy consumption, and content of total and organic selenium from different SePS extracts were determined.

The m6A reader IGF2BP1 contributes to the activation of hepatic stellate cells through facilitating TUBB4B mRNA stabilization.

The m6A reader insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) is involved in multiple pathophysiological processes through enhanced expression of the proteins encoded by their target mRNAs. However, the functional role of IGF2BP1-mediated m6A in liver fibrosis remains elusive. Here, we report that IGF2BP1 is highly expressed in activated hepatic stellate cells (HSCs), the major driver of fibrogenesis, and TUBB4B is identified as a potential target of IGF2BP1 by re-analysis of the RNA-seq, RIP-seq, and m6A-seq data.

Role of [F]FAPI-04 in staging and therapeutic management of intrahepatic cholangiocarcinoma: prospective comparison with [F]FDG PET/CT.

Background: Fluorine-18 fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) has some limitations in diagnosis of Intrahepatic cholangiocarcinoma (ICC).

Materials And Methods: Patients with histologically confirmed ICC who underwent both [F]FDG and F-labeled fibroblast-activation protein inhibitors ([F]FAPI)-04 PET/CT were prospectively analyzed. The maximum standard uptake value (SUV), tumor-to-background ratio (TBR), metabolic tumor volume (MTV), total lesion glycolysis (TLG), [F]FAPI-avid tumor volume (FTV), total lesion fibroblast activation protein expression (TLF) were compared between the two modalities by paired Wilcoxon signed-rank test and Mann-Whitney U test, and McNemar's test was used to assess the diagnostic accuracy between the two techniques.

Alginate-based artificial antigen presenting cells expand functional CD8 T cells with memory characteristics for adoptive cell therapy.

The development of artificial Antigen Presenting Cells (aAPCs) has led to improvements in adoptive T cell therapy (ACT), an immunotherapy, for cancer treatment. aAPCs help to streamline the consistent production and expansion of T cells, thus reducing the time and costs associated with ACT. However, several issues still exist with ACT, such as insufficient T cell potency, which diminishes the translational potential for ACT.

Analysis of risk factors and development of a nomogram prediction model for renal tubular acidosis in primary Sjogren syndrome patients.

Objective: To investigate the risk factors of renal tubular acidosis (RTA) in patients with primary Sjögren's syndrome (pSS) and create a personalized nomogram for predicting pSS-RTA patients.

Method: Data from 99 pSS patients who underwent inpatient treatment at our hospital from January 2012 to January 2024 were retrospectively collected and analyzed. Bootstrap resampling technique, single-factor, and multi-factor logistic regression analyses were used to explore the risk factors for pSS-RTA.

Source identification and migration fate of heavy metals of soil-groundwater system in a thousand-year cultivation region.

Pollution of farmland by heavy metals threatens food security and human health. In addition, heavy metals in soil could infiltrate into groundwater to influence the water quality and safety of drinking water. However, the relationship between heavy metal pollution in soil and groundwater is still not clear.

Correlation between serum trimethylamine-N-oxide and body fat distribution in middle-aged and older adults: a prospective cohort study.

Background: Trimethylamine-N-oxide (TMAO) is linked with obesity, while limited evidence on its relationship with body fat distribution. Herein, we investigated the associations between serum TMAO and longitudinal change of fat distribution in this prospective cohort study.

Methods: Data of 1964 participants (40-75y old) from Guangzhou Nutrition and Health Study (GNHS) during 2008-2014 was analyzed.

Dietary inflammatory index, mediating biomarkers and incident frailty in Chinese community-dwelling older adults.

Objectives: Diet can modulate systemic inflammation, while inflammation is a critical contributory factor of frailty. However, longitudinal data on the association between dietary inflammatory index (DII) and frailty are limited, and the intermediate mechanisms remain unclear. This study aimed to examine the association between DII and incident frailty and the potential mediating roles of frailty-related biomarkers.

Experimental insights and modeling innovations: Deciphering Fe(VI) oxidation in imidazole ionic liquids through QSAR and RFR.

In this investigation, we conducted a detailed analysis of the oxidation of 16 imidazole ionic liquid variants by Fe(VI) under uniform experimental setups, thereby securing a dataset of second-order reaction rate constants (k). This methodology ensures superior data consistency and comparability over traditional methods that amalgamate disparate data from varied studies. Utilizing 16 chemical structural parameters obtained via Density Functional Theory (DFT) as descriptors, we developed a Quantitative Structure Activity Relationship (QSAR) model.