Network embedding: The bridge between water distribution network hydraulics and machine learning.

Machine learning has been increasingly used to solve management problems of water distribution networks (WDNs). A critical research gap, however, remains in the effective incorporation of WDN hydraulic characteristics in machine learning. Here we present a new water distribution network embedding (WDNE) method that transforms the hydraulic relationships of WDN topology into a vector form to be best suited for machine learning algorithms.

Palladium-Catalyzed Dearomative Heck/C(sp)-H Activation/Decarboxylative Cyclization of C2-Tethered Indoles.

Until now, palladium-catalyzed dearomative Heck reactions of indoles were largely limited to β-H elimination and nucleophilic capture of the transient alkyl-Pd(II) species. Herein, we disclose a novel palladium-catalyzed dearomative Heck/C(sp)-H activation/decarboxylative cyclization of C2-tethered indoles. In this protocol, the alkyl-Pd(II) species formed by dearomatization of C2-tethered indoles is not terminated by common β-H elimination or nucleophilic capture, but rather generates ,-palladacycle via C-H activation.

Treatment of pediatric refractory or relapsed Epstein-Barr virus-associated hemophagocytic syndrome with PD-1 inhibitors.

Purpose: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a type of pediatric HLH that occurs frequently in Asia. Although immunochemotherapy based on etoposide and hormone has improved survival rates, there are still about 30% of HLH patients that do not respond. The objective of the article is to examine the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitors for children with relapsed/refractory (r/r) EBV-HLH.

A deep-level decomposed model to accelerate hydraulic simulations in large water distribution networks.

As the size of water distribution network (WDN) models continues to grow, developing and applying real-time models or digital twins to simulate hydraulic behaviors in large-scale WDNs is becoming increasingly challenging. The long response time incurred when performing multiple hydraulic simulations in large-scale WDNs can no longer meet the current requirements for the efficient and real-time application of WDN models. To address this issue, there is a rising interest in accelerating hydraulic calculations in WDN models by integrating new model structures with abundant computational resources and mature parallel computing frameworks.

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer's disease dementia.

Background: Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes reference genetic and transcriptomic data to estimate effect sizes of genetic variants on gene expression (i.e.

Computation-Driven Rational Design of Self-Assembled Short Peptides for Catalytic Hydrogen Production.

Self-assembling peptides represent a captivating area of study in nanotechnology and biomaterials. This interest is largely driven by their unique properties and the vast application potential across various fields such as catalytic functions. However, design complexities, including high-dimensional sequence space and structural diversity, pose significant challenges in the study of such systems.

The association between neighborhood-level social fragmentation and distressing psychotic-like experiences in early adolescence: the moderating role of close friends.

Background: Early exposure to neighborhood social fragmentation has been shown to be associated with schizophrenia. The impact of social fragmentation and friendships on distressing psychotic-like experiences (PLE) remains unknown. We investigate the relationships between neighborhood social fragmentation, number of friends, and distressing PLE among early adolescents.

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 93 risk genes for Alzheimer's disease dementia.

Background: Transcriptome-wide association study (TWAS) is an influential tool for identifying novel genes associated with complex diseases, where their genetic effects may be mediated through transcriptome. TWAS utilizes reference genetic and transcriptomic data to estimate genetic effect sizes on expression quantitative traits of target genes (i.e.

Association between intracerebral hemorrhage and cholesterol levels, and molecular mechanism underlying low cholesterol inhibiting autophagy in cerebral arterial smooth muscle cells leading to cell necrosis.

Background: An association between cholesterol and intracerebral hemorrhage (ICH) has been reported, but the mechanism is unclear.

Methods: In this cross-sectional study, participants aged 50-75 years were selected using multistage stratified cluster sampling. All samples completed a questionnaire (age, gender, medication, etc.

A convenient and stable graph-based pressure estimation methodology for water distribution networks: Development and field validation.

Accurate estimation of unknown nodal pressures (nodal heads) is necessary for efficient operation and management of water distribution networks (WDNs), but existing methods such as hydraulic simulation and data interpolation can hardly reconcile estimation accuracy with model construction and maintenance costs. Recent developments in graph signal processing (GSP) techniques provide us with new tools to utilize information in WDN hydraulics and available measurements. In a pilot study, a graph-based head reconstruction (GHR) method was proposed, which used GSP to reconstruct the spatially slow-varying parts of nodal heads from a limited number of field measurements to approximate original heads.

Maintaining the long-term accuracy of water distribution models with data assimilation methods: A comparative study.

The upgrading of water supply services is calling for more accurate and adaptive numerical models to give insight into actual water distribution systems (WDSs), which underlines the importance of carefully calibrating model parameters. Due to unavoidable uncertainties in the calibration process such as measurement errors, errors in model parameters assumed to be known, and local-optimum of calibration algorithms, calibrated parameters could still contain non-negligible latent errors, and the calibrated model may not able to maintain its long-term accuracy when operating conditions change. To solve this problem, there is growing interest in adopting data assimilation (DA) methods to utilize more comprehensive information in long-term measurements to reduce the impact of uncertainties and maintain the accuracy and stability of calibrated models.

Analysis of clinical characteristics and prognostic factors associated with EBV-associated HLH in children.

Purpose Our aim is to analyze the clinical characteristics and prognostic factors of Epstein-Barr (EB) virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children. Methods Children with newly diagnosed HLH were retrospectively analyzed. Results Finally, a total of 95 children with HLH were enrolled in this study, including 43 (45.

Research on Mask-Wearing Detection Algorithm Based on Improved YOLOv5.

COVID-19 is highly contagious, and proper wearing of a mask can hinder the spread of the virus. However, complex factors in natural scenes, including occlusion, dense, and small-scale targets, frequently lead to target misdetection and missed detection. To address these issues, this paper proposes a YOLOv5-based mask-wearing detection algorithm, YOLOv5-CBD.

Management of an Extensive Intraparotid and Auricular Arteriovenous Malformation.

BACKGROUND Extracranial arteriovenous malformations (AVMs) of the parotid gland and auricle are rarely encountered. Management of these AVMs depends on the Schobinger stage and their flow characteristics. We present a rare case of an AVM involving the parotid and auricle concurrently.

The Willingness of the Elderly to Choose Nursing Care: Evidence From in China.

With the accelerating aging of the population and the worsening psychological conditions of older people, the traditional mode of family support for the elderly in China does not always meet the physical and psychological needs of the elderly, and more social support modes for the elderly are needed. Based on 3,513 valid questionnaires on the long-term care and protection needs of Chinese residents, this paper uses a logit regression model to analyze the factors influencing the willingness of the elderly to choose nursing care. The results show that intergenerational family support for the elderly is a significant psychological driver on the willingness of the elderly to choose nursing care.

Stable, active CO reduction to formate via redox-modulated stabilization of active sites.

Electrochemical reduction of CO (COR) to formic acid upgrades waste CO; however, up to now, chemical and structural changes to the electrocatalyst have often led to the deterioration of performance over time. Here, we find that alloying p-block elements with differing electronegativities modulates the redox potential of active sites and stabilizes them throughout extended COR operation. Active Sn-Bi/SnO surfaces formed in situ on homogeneously alloyed BiSn crystals stabilize the COR-to-formate pathway over 2400 h (100 days) of continuous operation at a current density of 100 mA cm.

[Analysis of Clinical Characteristics and Prognosis in Children with Acute Megakaryoblastic Leukemia without Down Syndrome].

Objective: To analyze the clinical characteristics and treatment effects of children with acute megakaryoblastic leukemia without down syndrome (non-DS-AMKL).

Methods: The clinical data of 19 children with non-DS-AMKL treated in the Pediatric Hematology Ward in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from May 2008 to April 2018 were analyzed retrospectively. The clinical characteristics, laboratory test and treatment methods of the children were concluded.

[Efficacy of BMMSCs on aGVHD and Its Correlation with SerumInflammatory Cytokines in Pediatric Patients with Severe Refractory Acute Graft-Versus-Host Disease].

Objective: To investigate the efficacy of bone marrow mesenchymal stem cells (BMMSC) on children with refractory graft-versus-host disease (GVHD) and to judge the efficacy of BMMSC by dynamically monitoring the changes of cytokines in children with GVHD before and after infusion of BMMSC, so as to provide a theoretical basis for clarifying the mechanism of BMMSC.

Methods: 17 children with refractory aGVHD including 7 of grade II, 6 cases of grade III and 4 cases of grade IV after allo-HSCT were enrolled. All the children with aGVHD, who received routine immunosuppressive therapy, but the state of disease not improved, were treated with immunosuppressive drugs combined with BMMSC infusion.

[Clinical Analysis of 164 Children of Blood Disease Complicated with Invasive Fungal Disease].

Objective: To investigate the clinical characteristics, prevention and treatment of invasive fungal disease (IFD).

Methods: The clinical data of 164 patients who met the diagnostic criteria of IFD in our center from January 2012 to January 2015 were retrospectively analyzed. The incidence, clinical characteristics, related factors, treatment methods and prognosis were analyzed.

Diagnosis and treatment of juvenile myelomonocytic leukemia.

To investigate clinical features, diagnosis, treatment strategies and prognosis of juvenile myelomonocytic leukemia (JMML). The clinical data of 21 patients with JMML who were diagnosed in our hospital from January 2013 to May 2018 were retrospectively analyzed. Among the 21 children with JMML, 16 were male and 5 were female.

Accessory ossicles of the foot-an imaging conundrum.

Various anatomical variations can be found in the foot and ankle, including sesamoid bones and accessory ossicles. These are usually incidental findings and remain asymptomatic; however, they may cause complications resulting in painful syndromes or degenerative changes secondary to overuse or trauma. They can also lead to fractures or simulate fractures.

[Efficacy and Safety of MSC Infusion in Treatment of Children with Refractory LOHC: A Clinical Study].

Objective: To study the curative effect and safety of menchymal stem cell infusion in treatment of children with refractory late-onset hemorrhagic cystitis(LOHC) after allogeneic HSCT.

Methods: Thirty cases of children with refractory LOHC after allo-HSCT in our department between December 2010 and July 2016 were analyzed retrospectively, out of 30 cases 7 received MSC treatment. The used MSC of all were four-to-five generation MSC from bone marrows of third party donors, and were infused into patients with (1.

Epidemiological survey of human brucellosis in Inner Mongolia, China, 2010-2014: A high risk groups-based survey.

Brucellosis, a zoonosis which can seriously harm public health. Inner Mongolia is known as an endemic region of human brucellosis in China. The aim of this study is to present the epidemic of human brucellosis in Inner Mongolia from 2010 to 2014, and to provide the evidence of preventing from brucellosis in endemic areas.

Draft Genome Sequence of a Thermophilic Desulfurization Bacterium, Geobacillus thermoglucosidasius Strain W-2.

Geobacillus thermoglucosidasius strain W-2 is a thermophilic bacterium isolated from a deep-subsurface oil reservoir in northern China, which is capable of degrading organosulfur compounds. Here, we report the draft genome sequence of G. thermoglucosidasius strain W-2, which may help to elucidate the genetic basis of biodegradation of organosulfur pollutants under heated conditions.

[Expression of transient receptor potential canonical 1 in ozone-induced inflammatory lung tissues in mice].

Objective: To detect the expression of transient receptor potential canonical 1 (TRPC1) in a mouse model of ozone-induced lung inflammation and explore its role in lung inflammation.

Methods: In a mouse model of lung inflammation established by ozone exposure, the expression of TRPC1 in the inflammatory lung tissues was detected by RT-PCR, Wstern blotting and immunohistochemistry.

Results: Compared to the control mice, the mice exposed to ozone showed significantly increased expression level of TRPC1 mRNA and protein in the inflammatory lung tissues (P<0.