Computational simulations on the taste mechanism of steviol glycosides based on their interactions with receptor proteins.

Steviol glycoside (SG) is a potential natural sugar substitute. The taste of various SG structures differ significantly, while their mechanism has not been thoroughly investigated. To investigate the taste mechanism, molecular docking simulations of SGs with sweet taste receptor TAS1R2 and bitter taste receptor TAS2R4 were conducted.

The digestive behavior of pectin in human gastrointestinal tract: a review on fermentation characteristics and degradation mechanism.

Pectin is widely spread in nature and it develops an extremely complex structure in terms of monosaccharide composition, glycosidic linkage types, and non-glycosidic substituents. As a non-digestible polysaccharide, pectin exhibits resistance to human digestive enzymes, however, it is easily utilized by gut microbiota in the large intestine. Currently, pectin has been exploited as a novel functional component with numerous physiological benefits, and it shows a promising prospect in promoting human health.

Preparation of lignin containing cellulose nanofibers and its application in PVA nanocomposite films.

Lignin containing cellulose nanofibers (LCNFs) were successfully prepared from wheat straw using an acid hydrotrope of p-toluene sulfonic acid (p-TsOH) combined with ultrasonication. p-TsOH pretreatment was applied below 80 °C to selectively remove hemicellulose and lignin and generate purified cellulose fibers containing approximately 15% lignin. Subsequently, high-intensity ultrasonication was used for <6 min to effectively defibrillate the p-TsOH-pretreated cellulose fibers to nanoscale fibers.

Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome.

T cell immunoglobin and mucin domain (Tim)-4 on monocytes is involved in immune regulation. Here, we investigated Tim-4 expression on circulating monocytes and in plasma of ischemic stroke. Tim-4 expression was significantly increased on day 2 and day 5 after stroke.